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Plant extracts as potential mosquito larvicides

TLDR
The current state of knowledge on phytochemical sources and mosquitocidal activity, their mechanism of action on target population, variation of their larvicidal activity according to mosquito species, instar specificity, polarity of solvents used during extraction, nature of active ingredient and promising advances made in biological control of mosquitoes by plant derived secondary metabolites have been reviewed.
Abstract
Mosquitoes act as a vector for most of the life threatening diseases like malaria, yellow fever, dengue fever, chikungunya ferver, filariasis, encephalitis, West Nile Virus infection, etc. Under the Integrated Mosquito Management (IMM), emphasis was given on the application of alternative strategies in mosquito control. The continuous application of synthetic insecticides causes development of resistance in vector species, biological magnification of toxic substances through the food chain and adverse effects on environmental quality and non target organisms including human health. Application of active toxic agents from plant extracts as an alternative mosquito control strategy was available from ancient times. These are non-toxic, easily available at affordable prices, biodegradable and show broad-spectrum target-specific activities against different species of vector mosquitoes. In this article, the current state of knowledge on phytochemical sources and mosquitocidal activity, their mechanism of action on target population, variation of their larvicidal activity according to mosquito species, instar specificity, polarity of solvents used during extraction, nature of active ingredient and promising advances made in biological control of mosquitoes by plant derived secondary metabolites have been reviewed.

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Citations
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Essential oils and their compounds as Aedes aegypti L. (Diptera: Culicidae) larvicides: review

TL;DR: It is revealed that the essential oils are effective alternatives for the production of larvicides, which can be used in vector-borne disease control programmes.
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Plant extracts for developing mosquito larvicides: From laboratory to the field, with insights on the modes of action.

TL;DR: This review covers the huge amount of literature available on plant extracts tested as mosquito larvicides, particularly aqueous and alcoholic ones, due to their easy formulation in water without using surfactants, and concludes that 29 of them have outstanding larvicidal activity against major vectors belonging to the genera Anopheles, Aedes and Culex.
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Present and future potential of plant-derived products to control arthropods of veterinary and medical significance.

TL;DR: Though their current and future potential appears significant, development and deployment of PDPs to target veterinary and medical pests is not without issue, and encapsulation technologies and other slow-release mechanisms offer strong potential to improve residual activity where needed.
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Neem Oil and Crop Protection: From Now to the Future.

TL;DR: The potential use of neem oil in crop protection is reviewed, considering the gaps and obstacles associated with the development of sustainable agriculture in the not too distant future.
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A Review of Resistance Mechanisms of Synthetic Insecticides and Botanicals, Phytochemicals, and Essential Oils as Alternative Larvicidal Agents Against Mosquitoes

TL;DR: This review clearly indicates that the application of vegetal-based compounds as mosquito control proxies can serve as alternative biocontrol methods in mosquito management programes.
References
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Journal Article

Botanical derivatives in mosquito control: a review.

TL;DR: Examples of phytochemicals evaluated against mosquitoes as general toxicants, growth and reproduction inhibitors, repellents and ovipositional deterrents are given.
Journal ArticleDOI

Mechanism of action of insecticidal secondary metabolites of plant origin

TL;DR: The phytochemical biomolecules could be used for maximizing the effectiveness and specificity in future insecticide design with specific or multiple target sites, while ensuring the economic and ecological sustainability.
Journal ArticleDOI

A review of botanical phytochemicals with mosquitocidal potential.

TL;DR: The current state of knowledge on larvicidal plant species, extraction processes, growth and reproduction inhibiting phytochemicals, botanical ovicides, synergistic, additive and antagonistic joint action effects of mixtures, residual capacity, effects on non-target organisms, resistance, screening methodologies, and discuss promising advances made in phytochemical research are reviewed.
Journal Article

Insecticide resistance in mosquitoes: a pragmatic review

TL;DR: Descriptions of the World Health Organization standard methods of assessing susceptibility or resistance in larval and in adult mosquitoes are presented, and the evaluation of their results are discussed.
Journal ArticleDOI

Effect of Feronia limonia on mosquito larvae.

TL;DR: Bioassay guided fractionation of the acetone extract of Feronia limonia dried leaves afforded a potent mosquito larvicide, identified as n-hexadecanoic acid and found to be effective against fourth instar larvae of Culex quinquefasciatus, Anopheles stephensi and Aedes aegypti.
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