Journal ArticleDOI
Plasma uric acid level and its association with diabetes mellitus and some biologic parameters in a biracial population of fiji
TLDR
A strong renal involvement in the balance of plasma uric acid and may also reflect certain dietary patterns, such as a high intake of protein, fats, and certain local vegetables, which are found in Melanesians and Asian Indians.Abstract:
Plasma uric acid was investigated in a population survey on diabetes and cardiovascular risk factors among Melanesians and Asian Indians in Fiji in 1980. Plasma uric acid levels were elevated in men and women with impaired glucose tolerance in both ethnic groups. The lowest plasma uric acid levels were found in diabetic patients, especially in diabetic men. Even though obesity was positively associated with plasma uric acid, it did not explain the high plasma uric acid level in persons with impaired glucose tolerance. Body mass index had a significant and independent impact on plasma uric acid levels both in nondiabetic and diabetic men and women. The strongest predictor of plasma uric acid in the multiple regression analysis in our study populations was plasma creatinine: it alone explained 9% of the variation in men and 2% in women; and 24% in Melanesians and 5% in Asian Indians. Our findings suggest a strong renal involvement in the balance of plasma uric acid and may also reflect certain dietary patterns, such as a high intake of protein, fats, and certain local vegetables. Although the prevalence of hyperuricemia was high, 27% in both Melanesian men and women, 22% in Asian Indian men, and 11% in Asian Indian women, clinical gout was uncommon. Many predictor variables and their interactions were analyzed along with the reasons for the high plasma uric acid levels in persons with impaired glucose tolerance and for the low plasma uric acid levels in diabetic patients.read more
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Journal ArticleDOI
EULAR evidence based recommendations for gout. Part II: Management. Report of a task force of the EULAR Standing Committee For International Clinical Studies Including Therapeutics (ESCISIT)
Weiya Zhang,M. Doherty,Thomas Bardin,Eliseo Pascual,V. Barskova,P.G. Conaghan,J Gerster,J Jacobs,Burkhard F. Leeb,Frédéric Lioté,Geraldine M. McCarthy,Patrick Netter,George Nuki,Fernando Perez-Ruiz,A Pignone,J. Pimentao,Leonardo Punzi,Edward Roddy,Till Uhlig,Irena Zimmermann-Górska +19 more
TL;DR: 12 key recommendations for management of gout were developed, using a combination of research based evidence and expert consensus, based on a Delphi consensus approach.
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Hypothesis: Could Excessive Fructose Intake and Uric Acid Cause Type 2 Diabetes?
Richard J. Johnson,Santos E. Perez-Pozo,Yuri Y. Sautin,Jacek Manitius,Laura G. Sánchez-Lozada,Daniel I. Feig,Mohamed Shafiu,Mark S. Segal,Richard J. Glassock,Michiko Shimada,Carlos Roncal,Takahiko Nakagawa +11 more
TL;DR: It is proposed that excessive fructose intake (>50 g/d) may be one of the underlying etiologies of metabolic syndrome and type 2 diabetes and simple public health measures could have a major impact on improving the overall health of the populace.
Journal ArticleDOI
Antioxidant status in patients with uncomplicated insulin‐dependent and non‐insulin‐dependent diabetes mellitus
S. R. J. Maxwell,H. Thomason,D. Sandler,C Leguen,M. A. Baxter,Gary Thorpe,A. F. Jones,A. H. Barnett +7 more
TL;DR: It is shown that diabetic patients have significant defects of antioxidant protection, which may increase vulnerability to oxidative damage and the development of diabetic complications.
Journal ArticleDOI
Effect of insulin on uric acid excretion in humans
A. Quinones Galvan,Andrea Natali,Simona Baldi,Silvia Frascerra,G Sanna,Demetrio Ciociaro,Ele Ferrannini +6 more
TL;DR: Physiological hyperinsulinemia acutely reduces urinary UA and Na excretion in a coupled fashion and was associated with a 30% fall in urine Na excrete.
Journal ArticleDOI
Serum uric acid and risk for development of hypertension and impaired fasting glucose or Type II diabetes in Japanese male office workers.
TL;DR: The results indicate that SUA level is closely associated with an increased risk for hypertension and IFG or Type II diabetes, although the absolute risk was greater in more obese men.
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