Journal ArticleDOI
Polysaccharide-based aerogels as drug carriers
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TLDR
It has been shown that the release rate depends primary on the properties of the matrix and the preparation method and chemical nature of the gel phase, which demonstrates for the first time the high potential of polysaccharide aerogels for pharmaceutical applications.Abstract:
The application of aerogels as drug delivery system was successfully demonstrated for silica aerogels previously However, being biocompatible silica matrices are not biodegradable, which is a certain disadvantage for a number of pharmaceutically oriented applications For these purposes biodegradable materials are beneficial Supercritical drying of polysaccharide gels results in highly porous biodegradable aerogel matrices with large surface areas Structural properties of the polysaccharide aerogels depend on the preparation method and chemical nature of the gel phase In this work different polysaccharide precursors (starch, alginate) were used to produce aerogels, which later on were loaded with the drugs ibuprofen and paracetamol Furthermore release kinetics was studied in vitro Thereby it has been shown that the release rate depends primary on the properties of the matrix The presented results demonstrate for the first time the high potential of polysaccharide aerogels for pharmaceutical applicationsread more
Citations
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Journal ArticleDOI
Polysaccharide-based aerogels—Promising biodegradable carriers for drug delivery systems
TL;DR: This review focuses on the state-of-the-art of the production of polysaccharide-based aerogels with emphasis on the influence of processing parameters on the resulting end material properties.
Journal ArticleDOI
Biopolymer Aerogels and Foams: Chemistry, Properties, and Applications.
Shanyu Zhao,Wim J. Malfait,Natalia Guerrero-Alburquerque,Matthias M. Koebel,Gustav Nyström,Gustav Nyström +5 more
TL;DR: The biopolymer aerogel field today is driven forward by empirical materials discovery at the laboratory scale, but requires a firmer theoretical basis and pilot studies to close the gap to market.
Journal ArticleDOI
An emerging platform for drug delivery: aerogel based systems.
Zeynep Ulker,Can Erkey +1 more
TL;DR: This review presents an up to date overview of the advances in all kinds of aerogel based drug delivery systems which are currently under investigation.
Journal ArticleDOI
Supercritical drying of aerogels using CO2: Effect of extraction time on the end material textural properties
TL;DR: In this article, the supercritical carbon dioxide (scCO 2 ) of alcogels (in ethanol) was determined using a customized supercritical fluid extraction equipment, and the drying profile with different precursors (inorganic-silica-, organic-starch-), densities (silica aerogel of densities 0.08 and 0.15 ǫg/cm 3 ) and morphologies (cylindrical monoliths, microspheres) was studied.
Journal ArticleDOI
Synthesis and biomedical applications of aerogels: Possibilities and challenges
Hajar Maleki,Luísa Durães,Carlos A. García-González,Pasquale Del Gaudio,António Portugal,Morteza Mahmoudi,Morteza Mahmoudi +6 more
TL;DR: A comprehensive overview on the synthesis, processing and drying methods of the mostly investigated types of aerogels used in the biological and biomedical contexts, including silica aerogel, silica-polymer composites, polymeric and biopolymer aerogELs are provided.
References
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Journal ArticleDOI
Biological interactions between polysaccharides and divalent cations: The egg‐box model
TL;DR: It is shown that spedfic binding of divalent cations to a polysaechafide polyelectro]ym, leading firm cohesion between the chains, can cause characteristic effects in the c~rcutar diehroism spectrum which are understandabb in terms of modem theo~, [ l ].
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The roles of amylose and amylopectin in the gelation and retrogradation of starch
TL;DR: In this paper, the retrogradation of starch gels has been studied by using X-ray diffraction, differential scanning calorimetry, and measurements of the shear modulus.
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The Influence of Amylose on Starch Granule Structure
P.J. Jenkins,Athene M. Donald +1 more
TL;DR: In this study, small-angle X-ray scattering techniques have been applied to investigate the effect of varying amylose content on the internal structure of maize, barley and pea starch species and suggest thatAmylose disrupts the structural order within the amylopectin crystallites.
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The gelation and crystallisation of amylopectin
Stephen G. Ring,Paul Colonna,K.J. I'Anson,Monica T. Kalichevsky,Mervyn J Miles,Victor J. Morris,Paul D. Orford +6 more
TL;DR: A range of physical and chemical techniques, including viscometry, rheological measurements, dilatometry, turbidity measurements, X-ray diffraction, and differential scanning calorimetry, has been used to study the gelation of amylopectin this article.
Journal ArticleDOI
Gelation of amylose
TL;DR: A range of physical techniques, including light-scattering, turbidity measurements, viscometry, dilatometry, rheological measurements, and X-ray diffraction, have been used to study the gelation of amylose Gels form on cooling entangled amyloses solutions and occur as a result of a phase separation which produces a three-dimensional polymer network Crystallisation, as detected by X ray diffraction was observed to be a slower process originating in the polymer-rich phase as discussed by the authors.