Journal ArticleDOI
Portal and Peripheral Vein Immunoreactive Insulin Concentrations Before and After Glucose Infusion
TLDR
A significant positive correlation between portal vein and peripheral vein IRI responses to glucose was noted and the absolute amount of “big” insulin in the portal vein was similar during the first phase and the early part of the second phase of insulin secretion.Abstract:
Catheterization of the portal vein via the umbilical vein was performed under local anesthesia in twelve nondiabetic subjects prior to exploratory laporatomy for a variety of conditions. Immunoreactive insulin (IRI) in simultaneously obtained portal and peripheral vein plasma was determined before, during, and after a two-minute glucose infusion (25 gm.). Two phases of insulin secretion were apparent from portal vein IRI concentrations. A rapid secretory phase beginning one minute after start of the infusion and lasting three to four minutes was followed by a slower secretory phase beginning approximately ten minutes after start of the glucose infusion. The absolute amount of “big” insulin (proinsulin-like material) in the portal vein was similar during the first phase and the early part of the second phase of insulin secretion. A significant positive correlation between portal vein and peripheral vein IRI responses to glucose was noted.read more
Citations
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Fatty liver hepatitis (steatohepatitis) and obesity: an autopsy study with analysis of risk factors.
Ian R. Wanless,John S. Lentz +1 more
TL;DR: Statohepatitis (fatty liver hepatitis), histologically identical to alcoholic disease, occurs in some obese patients after jejunoileal bypass, and incidence of steatosis and steatohePatitis correlated with the degree of obesity.
Journal ArticleDOI
Effects of insulin on peripheral and splanchnic glucose metabolism in noninsulin-dependent (type II) diabetes mellitus.
TL;DR: The results emphasize the importance of the peripheral tissues in the disposal of infused glucose and indicate that muscle is the most important site of the insulin resistance in NIDD.
Journal ArticleDOI
Glucose metabolism during leg exercise in man
J. Wahren,J. Wahren,Philip Felig,Philip Felig,Gunvor Ahlborg,Gunvor Ahlborg,Lennart Jorfeldt,Lennart Jorfeldt +7 more
TL;DR: It is concluded that blood glucose becomes an increasingly important substrate for muscle oxidation during prolonged exercise of this type and peripheral glucose utilization increases in exercise despite a reduction in circulating insulin levels.
Journal Article
Regulation of splanchnic and periphral glucose uptake by insulin and hyperglycaemia in man
TL;DR: The effects of hyperinsulinemia and hyperglycemia on peripheral glucose uptake, hepatic glucose production, and splanchnic glucose uptake in man and the effects of somatostatin and glucagon replacement on these areas are investigated.
Journal ArticleDOI
A Model of the Kinetics of Insulin in Man
Robert S. Sherwin,Karl J. Kramer,Jordan D. Tobin,Paul A. Insel,John E. Liljenquist,Mones Berman,Reubin Andres +6 more
TL;DR: The design of the present study of the kinetics of insulin in man combines experimental features which obviate two of the major problems in previous insulin studies and concludes that compartment 3 insulin (rather than plasma insulin) is a more direct determinant of glucose utilization.
References
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Journal ArticleDOI
Immunoassay of Insulin: Two Antibody System: Plasma Insulin Levels of Normal, Subdiabetic and Diabetic Rats
Carl R Morgan,Arnold Lazarow +1 more
TL;DR: A two antibody system of insulin assay for immunoassay of insulin induces the production of specific nonprecipitating antibodies, both in experimental animals and in humans.
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The photometric microdetermination of blood glucose with glucose oxidase.
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Interpretation of the rapid intravenous glucose tolerance test in normal individuals and in mild diabetes mellitus
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"Big insulin": a new component of plasma insulin detected by immunoassay.
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Early phase of insulin release
TL;DR: It is postulated that impairment in the early phase of insulin release may be the first detectable abnormality of insulin secretion in diabetes mellitus and that glucagon has the capability of restoring this toward normal.