Postnatal changes in the expressions of serotonin 1A, 1B, and 2A receptors in ten brain stem nuclei of the rat: implication for a sensitive period.
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TLDR
A significant reduction in the expression of 5- HT(1A)R, 5-HT(1B) R, and 5-ht(2A) R in multiple respiratory-related nuclei at P12 is consistent with reduced serotonergic transmission during the critical period, thereby rendering the animals less able to respond adequately to ventilatory distress.About:
This article is published in Neuroscience.The article was published on 2010-01-13 and is currently open access. It has received 73 citations till now. The article focuses on the topics: Solitary tract nucleus & Nucleus raphe magnus.read more
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OtherDOI
Pontine mechanisms of respiratory control.
TL;DR: This review focuses on the pontine-mediated inspiratory off-switch (IOS) associated with postinspiratory glottal constriction, which is examined in the context of pontine regulation ofglottal resistance in response to multimodal sensory inputs and higher commands.
OtherDOI
Neuronal Control of Breathing: Sex and Stress Hormones
Mary Behan,Richard Kinkead +1 more
TL;DR: The role of sex hormones in respiratory control throughout life is reviewed, emphasizing how natural fluctuations in hormones are reflected in ventilatory metrics and how disruption of their endogenous cycle can predispose to respiratory disease.
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Excitatory–inhibitory imbalance in hypoglossal neurons during the critical period of postnatal development in the rat
TL;DR: Findings from recordings of single nerve cells show that, during this critical period of normal postnatal respiratory network development, the responses to excitation and those to inhibition are significantly enhanced, indicating that the system is under greater inhibitory influence at this time.
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Peripheral-central chemoreceptor interaction and the significance of a critical period in the development of respiratory control.
TL;DR: Carotid body denervation during the first two postnatal weeks in the rat profoundly affects the development and functions of central respiratory-related nuclei, suggesting that the critical period may be intrinsically and genetically determined.
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Decreased GABAA receptor binding in the medullary serotonergic system in the sudden infant death syndrome.
Kevin G. Broadbelt,David S. Paterson,Richard A. Belliveau,Felicia L. Trachtenberg,Elisabeth A. Haas,Christina Stanley,Henry F. Krous,Hannah C. Kinney +7 more
TL;DR: The data suggest that medullary GABAA receptors are abnormal in SIDS infants and that SIDS is a complex disorder of a homeostatic network in the medulla that involves deficits of the GABAergic and 5-HT systems.
References
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Book
The rat nervous system
TL;DR: The present work focuses on the development of brain Stem Systems Involved in the Blink Reflex, Feeding Mechanisms, and Micturition of the Spinal Cord, which are involved in the selection of somatic and emotional components of the Motor System in Mammals.
Book
Psychopharmacology: The Fourth Generation of Progress
Floyd E. Bloom,David J. Kupfer +1 more
TL;DR: Part 1 Preclinical section: critical analysis of methods transmitter systems - amino acids, amines, peptides, new transmitterscritical analysis of integrative concepts.
Journal Article
International Union of Pharmacology classification of receptors for 5-hydroxytryptamine (Serotonin).
Daniel Hoyer,David E. Clarke,John R. Fozard,Paul R. Hartig,Graeme R. Martin,Ewan J. Mylecharane,Pramod R. Saxena,Patrick P.A. Humphrey +7 more
TL;DR: It is evident that in the last decade or so, a vast amount of new information has become available concerning the various 5-HT receptor types and their characteristics, and it is important to rationalise in concert all of the available data from studies involving both operational approaches of the classical pharmacological type and those from molecular and cellular biology.
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Distribution of serotonin-immunoreactivity in the central nervous system of the rat-cell bodies and terminals.
TL;DR: The results demonstrate a widespread occurrence of 5-HT-positive nerve terminals throughout the central nervous system and the finding that serotonin-containing neurons are present in many nuclei that also include catecholamine- containing neurons makes it necessary to reconsider the terminology of the monoaminergic cell groups.
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Pre-Botzinger Complex: A Brainstem Region That May Generate Respiratory Rhythm in Mammals
TL;DR: The respiratory rhythm in the mammalian neonatal nervous system may result from a population of conditional bursting pacemaker neurons in the pre-Bötzinger Complex.