Potential Application of Combined Therapy with Lectins as a Therapeutic Strategy for the Treatment of Bacterial Infections
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In this paper, a review provides an update on the experimental application of antibiotic therapies based on the synergic combination with lectins to treat infections specifically caused by multidrug-resistant and biofilm-producing Staphylococcus aureus, Escherichia coli, and Pseudomonas aeruginosa.Abstract:
Antibiotic monotherapy may become obsolete mainly due to the continuous emergence of resistance to available antimicrobials, which represents a major uncertainty to human health. Taking into account that natural products have been an inexhaustible source of new compounds with clinical application, lectins are certainly one of the most versatile groups of proteins used in biological processes, emerging as a promising alternative for therapy. The ability of lectins to recognize carbohydrates present on the cell surface allowed for the discovery of a wide range of activities. Currently the number of antimicrobials in research and development does not match the rate at which resistance mechanisms emerge to an effective antibiotic monotherapy. A promising therapeutic alternative is the combined therapy of antibiotics with lectins to enhance its spectrum of action, minimize adverse effects, and reduce resistance to treatments. Thus, this review provides an update on the experimental application of antibiotic therapies based on the synergic combination with lectins to treat infections specifically caused by multidrug-resistant and biofilm-producing Staphylococcus aureus, Escherichia coli, and Pseudomonas aeruginosa. We also briefly discuss current strategies involving the modulation of the gut microbiota, its implications for antimicrobial resistance, and highlight the potential of lectins to modulate the host immune response against oxidative stress.read more
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A combination therapy strategy for treating antibiotic resistant biofilm infection using a guanidinium derivative and nanoparticulate Ag(0) derived hybrid gel conjugate
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TL;DR: The observed efficacy of this non-cytotoxic therapeutic combination (AD-L@Ag(0)) was found to be better than that reported in the existing literature for treating extremely drug-resistant bacterial strains, as well as for reducing the bacterial infection load at a surgical site in a small animal BALB/c model.
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Highly Synergistic Effects of Melittin With Vancomycin and Rifampin Against Vancomycin and Rifampin Resistant Staphylococcus epidermidis
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TL;DR: Melittin alone was effective against MDR-MRSE isolates and this antimicrobial peptide showed highly synergistic effects with vancomycin and rifampin without causing toxicity, suggesting the combination of melittin and traditional antibiotics could be a promising strategy for the treatment of infections caused by MDR -MRSE.
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References
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Journal ArticleDOI
Effect of Lactobacillus rhamnosus HN001 on carriage of Staphylococcus aureus : results of the impact of probiotics for reducing infections in veterans (IMPROVE) study
Shoshannah Eggers,Shoshannah Eggers,Anna K. Barker,Susan Valentine,Timothy Hess,Megan Duster,Nasia Safdar,Nasia Safdar +7 more
TL;DR: Use of daily oral L. rhamnosus HN001 reduced odds of carriage of S. aureus in the GI tract, however it did not eradicate S.aureus from other body sites.
Journal ArticleDOI
Parkia platycephala lectin enhances the antibiotic activity against multi-resistant bacterial strains and inhibits the development of Haemonchus contortus
Romerio R.S. Silva,Carolina R. Silva,Valdenice F. Santos,Cristina Rodrigues dos Santos Barbosa,Débora Feitosa Muniz,Ana L.E. Santos,Maria H.C. Santos,Bruno A.M. Rocha,Karla L.R. Batista,Lívio Martins Costa-Júnior,Henrique Douglas Melo Coutinho,Claudener S. Teixeira +11 more
TL;DR: It can be concluded that PPL showed selective anthelmintic effect, inhibiting the development of H. contortus larvae and that it increased the effect of the antibiotic gentamicin against multi-resistant bacterial strains, thus constituting a potential therapeutic resource against resistant bacterial strains and H.contortus.
Journal ArticleDOI
Pharmaceutical applications of lectins
Laura Lavín de Juan,Veronica García Recio,Pilar Jiménez López,Tomás Girbés Juan,Manuel Cordoba-Diaz,Damián Cordoba-Diaz +5 more
TL;DR: Both direct and reverse lectin targeting studies has been analyzed, specifically those focusing on drug targeting to the intestine, and this strategy is not only useful in intestinal diseases, but also provides an increase in the systemic absorption of drugs.
Journal ArticleDOI
Polyphenolic Nutraceuticals to Combat Oxidative Stress Through Microbiota Modulation
TL;DR: The action of the nutraceuticals are highlighted in minimizing the oxidative stress by directly influencing the microbiota and slowing down the inflammatory progression.
Journal ArticleDOI
Modulation of the Antibiotic Activity by the Mauritia flexuosa (Buriti) Fixed Oil against Methicillin-Resistant Staphylococcus Aureus (MRSA) and Other Multidrug-Resistant (MDR) Bacterial Strains.
Yara Faustino Pereira,Maria do Socorro Costa,Saulo R. Tintino,Janaína Esmeraldo Rocha,Fábio Fernandes Galvão Rodrigues,Maria Karine De Sá Barreto Feitosa,Irwin Rose Alencar de Menezes,Henrique Douglas Melo Coutinho,José Galberto Martins da Costa,Erlânio Oliveira de Sousa +9 more
TL;DR: The data indicates the M. flexuosa fixed oil as a valuable source of oleic acid and modulator of aminoglycoside activity and its antibacterial and aminglycoside antibiotic modifying activity against Gram-positive and Gram-negative multiresistant bacterial strains.