Journal ArticleDOI
Prediction of mechanical properties of human trabecular bone by electrical measurements
Joanna Sierpowska,Mikko Hakulinen,Juha Töyräs,J. S. Day,Harrie Weinans,Jukka S. Jurvelin,Reijo Lappalainen +6 more
TLDR
The results suggest that the measurements of low frequency electrical and dielectric properties may provide information on the mechanical status of trabecular bone and, possibly, may even help to diagnose bone microdamage.Abstract:
In trabecular bone, the interrelationships of electrical and dielectric properties with mechanical characteristics are poorly known. Information on these relations is crucial for evaluation of the diagnostic potential of impedance techniques. In this study, electrical and dielectric properties, i.e. permittivity, conductivity, phase angle, loss factor, specific impedance and dissipation factor of human trabecular bone samples (n = 26, harvested from the distal femur and proximal tibia) were characterized in a wide frequency range (50 Hz-5 MHz). Mechanical properties, i.e. Young's modulus, ultimate strength, yield stress, yield strain and resilience of the samples (n = 20) were determined by using destructive compressive testing. Subsequently, measurements of electrical and dielectric properties were repeated after mechanical testing. The measurements were also repeated for the control samples (n = 6) that were not mechanically tested. Electrical, dielectric or mechanical properties showed no significant differences between the intact femoral and tibial samples. The electrical and dielectric parameters as well as the linear correlations between the dielectric and electrical parameters with mechanical parameters were strongly frequency dependent. At the frequency of 1.2 MHz, the relative permittivity showed the strongest linear correlations with the Young's modulus (r = 0.71, p < 0.01, n = 20) and ultimate strength (r = 0.73, p < 0.01, n = 20). Permittivity and dissipation factor showed statistically significant changes after mechanical testing. Our results suggest that the measurements of low frequency electrical and dielectric properties may provide information on the mechanical status of trabecular bone and, possibly, may even help to diagnose bone microdamage. In the future, these measurement techniques may be further developed for use during open surgery, such as bone grafting or total hip replacement surgery.read more
Citations
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Journal ArticleDOI
Porous hydroxyapatite/gelatine scaffolds with ice-designed channel-like porosity for biomedical applications
TL;DR: The compressive mechanical properties of lamellar scaffolds improved with the addition of gelatine: the strength increased up to 5-6 times, while the elastic modulus and strain approximately doubled, and the effectiveness of the cross-linkage has been preliminarily verified following scaffold degradation in synthetic body fluid.
Journal ArticleDOI
Preparation of novel porous calcium silicate scaffold loaded by celecoxib drug using freeze drying technique: Fabrication, characterization and simulation
TL;DR: In this paper, the microarchitecture of bio-nanocomposite scaffold, which is fabricated by natural synthetic diopside and composed of magnetite nanoparticles (MNPs), is considered.
Journal ArticleDOI
Standardizing compression testing for measuring the stiffness of human bone
TL;DR: Suggestions for bone compression testing are made in this review, although further studies are needed to establish standardized bone testing techniques in order to increase the comparability and reliability of bone stiffness studies.
Journal ArticleDOI
Synthesis and characterization of hydroxyapatite nanoparticles prepared by a high-gravity precipitation method
TL;DR: In this paper, a high-gravity precipitation method was used to synthesize hydroxyapatite nanoparticles (nHAP) using X-ray diffraction and transmission electron microscopy (TEM).
Journal ArticleDOI
Effect of human trabecular bone composition on its electrical properties
Joanna Sierpowska,Mikko J. Lammi,Mikko Hakulinen,Jukka S. Jurvelin,Reijo Lappalainen,Juha Töyräs +5 more
TL;DR: If the trabecular bone composition is known, the relationships presented in this study could facilitate calculation of current field distribution, e.g. during electrical stimulation of osteogenesis, and the results suggest that permittivity measured at low (<1 kHz) or high (>100 kHz) frequencies could be used for prediction of trabECular bone water or fat contents, respectively.
References
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Journal ArticleDOI
The dielectric properties of biological tissues: I. Literature survey
TL;DR: The dielectric properties of tissues have been extracted from the literature of the past five decades and presented in a graphical format to assess the current state of knowledge, expose the gaps there are and provide a basis for the evaluation and analysis of corresponding data from an on-going measurement programme.
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Charles H. Turner,David B. Burr +1 more
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TL;DR: The classical principles behind dielectric relaxation are summarized, as empirical correlations with tissue water content in other compositional variables, and a comprehensive table is presented of dielectrics properties.
Journal ArticleDOI
Biomechanics of trabecular bone.
TL;DR: The state of the art in trabecular bone biomechanics is reviewed, focusing on the mechanical aspects, and attempts to identify important areas of current and future research.
Journal ArticleDOI
The effect of different storage methods on the mechanical properties of trabecular bone
TL;DR: The elastic and viscoelastic properties of trabecular bone was examined using non-destructive compression tests to 0.45% specimen strain and showed significant although small changes during 100 d of storage.
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