Predominance of Cronobacter sakazakii Sequence Type 4 in Neonatal Infections
Susan Joseph,Stephen J. Forsythe +1 more
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C. sakazakii ST4 appears to be a highly stable clone with a high propensity for neonatal meningitis and sequence type (ST) 4 is associated with neonatalMeningitis.Abstract:
A 7-loci (3,036 nt) multilocus sequence typing scheme was applied to 41 clinical isolates of Cronobacter sakazakii. Half (20/41) of the C. sakazakii strains were sequence type (ST) 4, and 9/12 meningitis isolates were ST4. C. sakazakii ST4 appears to be a highly stable clone with a high propensity for neonatal meningitis.read more
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Cronobacter condimenti sp. nov., isolated from spiced meat, and Cronobacter universalis sp. nov., a species designation for Cronobacter sp. genomospecies 1, recovered from a leg infection, water and food ingredients.
Susan Joseph,Esin Cetinkaya,Hana Drahovská,Arturo Levican,Maria José Figueras,Stephen J. Forsythe +5 more
TL;DR: DNA-DNA reassociation and phenotypic analysis confirmed that these strains represent a novel species, for which the name Cronobacter universalis sp.
Journal ArticleDOI
Diversity of the Cronobacter Genus as Revealed by Multilocus Sequence Typing
Susan Joseph,Hana Sonbol,Sumyya Hariri,Prerak T. Desai,Michael McClelland,Stephen J. Forsythe +5 more
TL;DR: A multilocus sequence typing (MLST) approach employing the alleles of 7 genes was used to investigate the phylogenetic relationship of 325 Cronobacter species isolates and found C. sakazakii sequence type 4 was the predominant sequence type of cerebral spinal fluid isolates from cases of meningitis.
Journal ArticleDOI
Cronobacter spp. as emerging causes of healthcare-associated infection
O. Holý,Stephen J. Forsythe +1 more
TL;DR: International improvements in the microbiological safety of PIF and advice on feeding practices have focused on improving neonatal health care following the heightened awareness of Cronobacter infections in this particular age group, but a number of unresolved issues remain.
Journal ArticleDOI
Cronobacter species (formerly known as Enterobacter sakazakii) in powdered infant formula: a review of our current understanding of the biology of this bacterium
TL;DR: An up‐to‐date review of the current knowledge of Cronobacter species is presented, and consideration is given to the control of this organism in the manufacturing environment, as a first step towards reducing the occurrence of this pathogen in PIF.
Journal ArticleDOI
Cronobacter, the emergent bacterial pathogen Enterobacter sakazakii comes of age; MLST and whole genome sequence analysis
TL;DR: Next Generation Sequencing to Cronobacter meets the WHO (2004) request for the establishment of a typing scheme for this emergent bacterial pathogen and offers a central, open access, reliable sequence-based repository for researchers.
References
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Journal ArticleDOI
Enterobacter sakazakii: A New Species of “Enterobacteriaceae” Isolated from Clinical Specimens
TL;DR: Enterobacter sakazakii is the name proposed for the organism previously known as “yellow-pigmented Enterobacter cloacae,” which has been isolated from human clinical specimens such as sputum, feces, and wounds, where it is probably only a colonizer and not clinically significant.
Journal Article
Enterobacter sakazakii infections associated with the use of powdered infant formula-Tennessee, 2001
TL;DR: This report summarizes the investigation of a fatal infection associated with E. sakazakii in a hospitalized neonate, which indicated that the infection was associated with the presence of the organism in commercial powdered formula fed to the infant.
Journal ArticleDOI
Invasive Enterobacter sakazakii Disease in Infants
Anna Bowen,Christopher R. Braden +1 more
TL;DR: Analyzing 46 cases of invasive infant E. sakazakii infection to define risk factors and guide prevention and treatment found infants with meningitis had greater birthweight and gestational age, and infection developed at a younger age.
Journal ArticleDOI
Analysis of eight cases of neonatal meningitis and sepsis due to Enterobacter sakazakii.
TL;DR: Eight cases of neonatal meningitis due to Enterobacter sakazakii which occurred in The Netherlands during the last 6 years were investigated retrospectively, finding strains were much more susceptible to some of the new beta-lactam antibiotics than to ampicillin.
Journal ArticleDOI
Genome Sequence of Cronobacter sakazakii BAA-894 and Comparative Genomic Hybridization Analysis with Other Cronobacter Species
Eva Kucerova,Sandra W. Clifton,Xiao-Qin Xia,Fred Long,Steffen Porwollik,Lucinda Fulton,Catrina Fronick,Patrick Minx,Kim Kyung,Wesley C. Warren,Robert A. Fulton,Dongyan Feng,Aye Wollam,Neha Shah,Veena Bhonagiri,William E. Nash,Kymberlie Hallsworth-Pepin,Richard K. Wilson,Michael McClelland,Stephen J. Forsythe +19 more
TL;DR: A number of genes unique to Cronobacter species associated with neonatal infections (C. sakazakii, C. malonaticus and C. turicensis) were identified and included a copper and silver resistance system known to be linked to invasion of the blood-brain barrier by neonatal meningitic strains of Escherichia coli.
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Genome Sequence of Cronobacter sakazakii BAA-894 and Comparative Genomic Hybridization Analysis with Other Cronobacter Species
Eva Kucerova,Sandra W. Clifton,Xiao-Qin Xia,Fred Long,Steffen Porwollik,Lucinda Fulton,Catrina Fronick,Patrick Minx,Kim Kyung,Wesley C. Warren,Robert A. Fulton,Dongyan Feng,Aye Wollam,Neha Shah,Veena Bhonagiri,William E. Nash,Kymberlie Hallsworth-Pepin,Richard K. Wilson,Michael McClelland,Stephen J. Forsythe +19 more