Journal ArticleDOI
Prefrontal and medial temporal lobe interactions in long-term memory
Jon S. Simons,Hugo J. Spiers +1 more
TLDR
Advances in functional neuroimaging, neurophysiology, crossed-lesion neuropsychology and computational modelling highlight the importance of understanding how the medial temporal and frontal lobes interact to allow successful remembering, and provide an opportunity to explore these interactions.Abstract:
Cognitive neuroscience has made considerable progress in understanding the involvement of the medial temporal and frontal lobes in long-term memory. Whereas the medial temporal lobe has traditionally been associated with the encoding, storage and retrieval of long-term memories, the prefrontal cortex has been linked with cognitive control processes such as selection, engagement, monitoring and inhibition. However, there has been little attempt to understand how these regions might interact during encoding and retrieval, and little consideration of the anatomical connections between them. Recent advances in functional neuroimaging, neurophysiology, crossed-lesion neuropsychology and computational modelling highlight the importance of understanding how the medial temporal and frontal lobes interact to allow successful remembering, and provide an opportunity to explore these interactions.read more
Citations
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Updating P300: An Integrative Theory of P3a and P3b
TL;DR: The empirical and theoretical development of the P300 event-related brain potential is reviewed by considering factors that contribute to its amplitude, latency, and general characteristics.
Journal ArticleDOI
Visual objects in context
TL;DR: Building on previous findings, the knowledge that is available is reviewed, specific mechanisms for the contextual facilitation of object recognition are proposed, and important open questions are highlighted.
Journal ArticleDOI
Intermediate phenotypes and genetic mechanisms of psychiatric disorders
TL;DR: Recent advances, challenges and implications of linking genes to structural and functional variation in brain systems related to cognition and emotion are illustrated.
Journal ArticleDOI
The nature of individual differences in working memory capacity: active maintenance in primary memory and controlled search from secondary memory.
Nash Unsworth,Randall W. Engle +1 more
TL;DR: A framework is used to examine previous individual differences studies of working memory capacity, and new evidence is examined on the basis of predictions of the framework to performance on immediate free recall.
Journal ArticleDOI
Deconstructing episodic memory with construction
TL;DR: It is argued that the process of 'scene construction' is better able to account for the commonalities in the brain areas engaged by an extended range of disparate functions.
References
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Book
The Hippocampus as a Cognitive Map
John O'Keefe,Lynn Nadel +1 more
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Journal ArticleDOI
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TL;DR: The results of these studies point to the importance of the hippocampal complex for normal memory function in patients who had undergone similar, but less radical, bilateral medial temporallobe resections, and as a warning to others of the risk to memory involved in bilateral surgical lesions of the hippocampusal region.
Journal ArticleDOI
Place navigation impaired in rats with hippocampal lesions.
TL;DR: It is reported that, in addition to a spatial discrimination impairment, total hippocampal lesions also cause a profound and lasting placenavigational impairment that can be dissociated from correlated motor, motivational and reinforcement aspects of the procedure.
Journal ArticleDOI
The hippocampus as a spatial map. Preliminary evidence from unit activity in the freely-moving rat
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Journal ArticleDOI
Memory and the hippocampus: A synthesis from findings with rats, monkeys, and humans.
TL;DR: The role of the hippocampus is considered, which is needed temporarily to bind together distributed sites in neocortex that together represent a whole memory.