Prevalence and Clinical Symptoms of Human Metapneumovirus Infection in Hospitalized Patients
Bernadette G. van den Hoogen,Gerard J. J. van Doornum,John C. Fockens,Jan J. Cornelissen,Walter E.P. Beyer,Ronald de Groot,Albert D. M. E. Osterhaus,Ron A. M. Fouchier +7 more
TLDR
In this article, the authors performed a 17-month period analysis of the prevalence of and clinical symptoms associated with human metapneumovirus (hMPV) infection, among patients in a university hospital in The Netherlands.Abstract:
During a 17-month period, we performed retrospective analyses of the prevalence of and clinical symptoms associated with human metapneumovirus (hMPV) infection, among patients in a university hospital in The Netherlands. All available nasal-aspirate, throat-swab, sputum, and bronchoalveolar-lavage samples (N=1515) were tested for hMPV RNA by reverse-transcriptase polymerase chain reaction. hMPV RNA was detected in 7% of samples from patients with respiratory tract illnesses (RTIs) and was the second-most-detected viral pathogen in these patients during the last 2 winter seasons. hMPV was detected primarily in very young children and in immunocompromised individuals. In young children, clinical symptoms associated with hMPV infection were similar to those associated with human respiratory syncytial virus (hRSV) infection, but dyspnea, feeding difficulties, and hypoxemia were reported more frequently in hRSV-infected children. Treatment with antibiotics and corticosteroids was reported more frequently in hMPV-infected children. From these data, we conclude that hMPV is an important pathogen associated with RTI.read more
Citations
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A previously undescribed coronavirus associated with respiratory disease in humans.
Ron A. M. Fouchier,Nico G. Hartwig,Theo M. Bestebroer,Berend Niemeyer,Jan C. de Jong,James H. M. Simon,Albert D. M. E. Osterhaus +6 more
TL;DR: The identification and characterization of a not previously recognized coronavirus obtained from an 8-mo-old boy suffering from pneumonia is described, revealing that it is most closely related to porcine epidemic diarrhea virus and HCoV 229E.
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Detection of Respiratory Viruses by Molecular Methods
TL;DR: The application of nucleic acid amplification technology, particularly multiplex PCR coupled with fluidic or fixed microarrays, provides an important new approach for the detection of multiple respiratory viruses in a single test.
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COPD exacerbations · 2: Aetiology
TL;DR: How an exacerbation should be defined, its inflammatory basis, and the importance of exacerbations on disease progression are reviewed, and important aetiologies, with their potential underlying mechanisms, are discussed.
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Antigenic and Genetic Variability of Human Metapneumoviruses
Bernadette G. van den Hoogen,Sander Herfst,Leo Sprong,Patricia A. Cane,Eduardo Forleo-Neto,Rik L. de Swart,Albert D. M. E. Osterhaus,Ron A. M. Fouchier +7 more
TL;DR: On the basis of sequence diversity between attachment protein genes and the differences in virus neutralization titers, two HMPV serotypes were defined and each serotype could be divided into two genetic lineages, but these did not reflect major antigenic differences.
References
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A newly discovered human pneumovirus isolated from young children with respiratory tract disease.
Bernadette G. van den Hoogen,Jan C. de Jong,Jan Groen,Thijs Kuiken,Ronald de Groot,Ron A. M. Fouchier,Albert D. M. E. Osterhaus +6 more
TL;DR: Serological studies showed that by the age of five years, virtually all children in the Netherlands have been exposed to human metapneumovirus and that the virus has been circulating in humans for at least 50 years.
Journal ArticleDOI
Respiratory syncytial virus in early life and risk of wheeze and allergy by age 13 years.
Renato T. Stein,Duane L. Sherrill,Wayne J. Morgan,Catharine J. Holberg,Marilyn Halonen,Lynn M. Taussig,Anne L. Wright,Fernando D. Martinez +7 more
TL;DR: RSV lower respiratory tract illnesses in early childhood are an independent risk factor for the subsequent development of wheezing up to age 11 years but not at age 13, and this association is not caused by an increased risk of allergic sensitisation.
Book
Statistics with confidence
TL;DR: Uncertainty and Psychological Research Variables and Measurement Exploring, Describing, Displaying and Summarizing Research Design and Probability Sampling Distributions and Confidence Intervals Statistical Models and Significance Tests Predicting a Quantitative Variable from a Categorical Variable The t Test and Analysis of Variance Quantitative Predictors Regression and Correlation Predicting categorical Variables Contingency Tables and Chi-square More than Two Variables A Peek at Multivariate Analysis Putting Statistics into Perspective
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Risk of primary infection and reinfection with respiratory syncytial virus
TL;DR: The risk of reinfection was inversely related to the level of neutralizing antibodies in the serum of the children, and the risk decreased to only 33.3% during year 4.
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Respiratory Syncytial Virus Bronchiolitis in Infancy Is an Important Risk Factor for Asthma and Allergy at Age 7
TL;DR: RSV bronchiolitis in infancy severe enough to cause hospitalization was highly associatied with the development of asthma and allergic sensitization up to age 7(1)/ (2).