Journal ArticleDOI
Prevention of left ventricular remodeling by long-term corticosteroid therapy in patients with cardiac sarcoidosis.
Chiung-Zuan Chiu,Satoshi Nakatani,Guican Zhang,Teruo Tachibana,Fumio Ohmori,Masakazu Yamagishi,Masafumi Kitakaze,Hitonobu Tomoike,Kunio Miyatake +8 more
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TLDR
In this article, the effectiveness of corticosteroids to prevent left ventricular (LV) remodeling and improve LV contractility was evaluated in patients with cardiac sarcoidosis.Abstract:
Forty-three patients with cardiac sarcoidosis were studied echocardiographically before and after (mean follow-up 88 months) steroid therapy to determine the effectiveness of corticosteroids to prevent left ventricular (LV) remodeling and improve LV contractility. In patients with initial LV ejection fractions (LVEFs) ≥55%, long-term steroid therapy showed preventive effects for LV remodeling and LV function. Patients with LVEFread more
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HRS Expert Consensus Statement on the Diagnosis and Management of Arrhythmias Associated With Cardiac Sarcoidosis
David H. Birnie,William H. Sauer,Frank Bogun,Joshua M. Cooper,Daniel A. Culver,Claire S. Duvernoy,Marc A. Judson,Jordana Kron,Davendra Mehta,Jens Cosedis Nielsen,Amit R. Patel,Tohru Ohe,Pekka Raatikainen,Kyoko Soejima +13 more
TL;DR: This research presents a meta-anatomy of the autonomic nervous system, a probabilistic model of how the immune system regulates emotion, language, and physical activity in relation to heart disease.
Journal ArticleDOI
Cardiac sarcoidosis: epidemiology, characteristics, and outcome over 25 years in a nationwide study.
Riina Kandolin,Jukka Y. A. Lehtonen,Juhani Airaksinen,Tapani Vihinen,Heikki Miettinen,Kari Ylitalo,Kari S. Kaikkonen,Suvi Sirkku Tuohinen,Petri Haataja,Tuomas Kerola,Jorma O. Kokkonen,Markus Pelkonen,Päivi Pietilä-Effati,Seppo Utrianen,Markku Kupari +14 more
TL;DR: In this article, a study was designed to assess the epidemiology, characteristics and outcome of cardiac sarcoidosis (CS) in Finland by identifying all adult (>18 yr) patients diagnosed with histologically confirmed CS in Finland between 1988 and 2012.
Journal ArticleDOI
Review ArticleCardiac sarcoidosis
Jessica S. Kim,Marc A. Judson,Robert Donnino,Michael S. Gold,Leslie T. Cooper,Eric N. Prystowsky,Stephen Prystowsky +6 more
TL;DR: All patients diagnosed with sarcoidosis should be screened for cardiac involvement and patients with CS and symptoms such as syncope need an aggressive workup for a potentially life-threatening etiology, and often require implantable cardioverter-defibrillator therapy.
Journal ArticleDOI
Cardiac sarcoidosis: a comprehensive review.
TL;DR: Considering the increased risk of sudden death, cardiac sarcoidosis is an indication for early treatment with corticosteroids or other immunosuppressive agents, and in refractory cases, cardiac transplantation should be considered.
Journal ArticleDOI
Reduction in 18F-fluorodeoxyglucose uptake on serial cardiac positron emission tomography is associated with improved left ventricular ejection fraction in patients with cardiac sarcoidosis
Michael T. Osborne,Edward Hulten,Avinainder Singh,Alfonso H. Waller,Márcio Sommer Bittencourt,Garrick C. Stewart,Jon Hainer,Venkatesh L. Murthy,Hicham Skali,Sharmila Dorbala,Marcelo F. Di Carli,Ron Blankstein +11 more
TL;DR: In a longitudinal cohort of CS patients, a reduction in the intensity and extent of myocardial inflammation on FDG PET is associated with improvement in EF, and serial PET scanning may help guide titration of immunosuppressive therapy to improve or prevent heart failure in CS.
References
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Journal ArticleDOI
A study of sarcoidosis; based on a combined investigation of 160 cases including 30 autopsies from The Johns Hopkins Hospital and Massachusetts General Hospital.
W T Longcope,D G Freiman +1 more
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Prognostic determinants of long-term survival in Japanese patients with cardiac sarcoidosis treated with prednisone
Yoshikazu Yazaki,Mitsuaki Isobe,Michiaki Hiroe,Shin-ichiro Morimoto,Shinya Hiramitsu,Takeshi Nakano,Tohru Izumi,Morie Sekiguchi +7 more
TL;DR: The severity of heart failure was one of the most significant independent predictors of mortality for cardiac sarcoidosis and starting corticosteroids before the occurrence of systolic dysfunction resulted in an excellent clinical outcome.
Journal ArticleDOI
Histologic diagnostic rate of cardiac sarcoidosis: Evaluation of endomyocardial biopsies
Akihisa Uemura,Shin-ichiro Morimoto,Shinya Hiramitsu,Yasuchika Kato,Teruo Ito,Hitoshi Hishida +5 more
TL;DR: The diagnostic rate achieved with biopsy in cardiac sarcoidosis is low; the patients with sarcoIDosis and evidence of significant cardiac involvement should be treated for cardiac sarCOidosis despite negative myocardial biopsies for this disease.