Journal ArticleDOI
Priapism and impotence in homozygous sickle cell disease.
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TLDR
A questionnaire study of Jamaican patients with homozygous sickle cell (SS) disease indicated a 42% prevalence of priapism, with a median age at onset of 21 years, and Hematologic analysis indicated that priapisms was significantly associated with low hemoglobin F levels and high platelet counts.Abstract:
• A questionnaire study of Jamaican patients with homozygous sickle cell (SS) disease indicated a 42% prevalence of priapism, with a median age at onset of 21 years. Two predominantly different patterns of priapism were recorded: short "stuttering" episodes lasting less than three hours, with normal consequent sexual function, and severe prolonged attacks (generally more than 24 hours) commonly followed by impotence. Stuttering episodes were frequently a prodrome to a major attack. Over one fourth of those who had suffered priapism had some degree of impotence. Hematologic analysis indicated that priapism was significantly associated with low hemoglobin F levels and high platelet counts. Patients with severe attacks of priapism had lower hemoglobin F levels and reticulocyte count, and a higher mean corpuscular volume, than patients with only stuttering episodes. Priapism and impotence contribute to the morbidity of SS disease more frequently than previously recognized. (Arch Intern Med140:1434-1437, 1980)read more
Citations
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Nitric oxide: a physiologic mediator of penile erection
TL;DR: No is established as a physiologic mediator of erectile function and small doses of NO synthase inhibitors abolished electrophysiologically induced penile erections.
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Intravascular hemolysis and the pathophysiology of sickle cell disease
TL;DR: Intravascular hemolysis represents an intrinsic mechanism for human vascular disease that manifests clinical complications in sickle cell disease and other chronic hereditary or acquired hemolytic anemias.
Journal ArticleDOI
The epidemiology of erectile dysfunction.
Alexandru E. Benet,Arnold Melman +1 more
TL;DR: More epidemiologic research is essential to further understand the distribution as well as the prevalence of ED in certain ethnic groups, chronic conditions, and as a result of surgery and trauma.
Journal ArticleDOI
Priapism: Pathogenesis, Epidemiology, and Management
Gregory A. Broderick,Ates Kadioglu,Trinity J. Bivalacqua,Hussein Ghanem,Ajay Nehra,Rany Shamloul,Rany Shamloul,Rany Shamloul +7 more
TL;DR: Broderick et al. as mentioned in this paper provided a comprehensive review of the evidence-based guidelines written over the past decade and reviewed the priapism literature from 2003 to 2009, concluding that prompt diagnosis and appropriate management are necessary to spare patients ineffective interventions and maximize erectile function outcomes.
Journal ArticleDOI
Genetic modifiers of sickle cell disease
TL;DR: Understanding the genetics underlying the heritable subphenotypes of sickle cell anemia would be prognostically useful, could inform personalized therapeutics, and might help the discovery of new “druggable” pathophysiologic targets.
References
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Journal ArticleDOI
Intensive transfusion therapy for priapism in boys with sickle cell anemia.
Journal ArticleDOI
Priapism associated with sickle cell disease.
Howard B. Hasen,Samuel L. Raines +1 more
Journal ArticleDOI
Priapism in Children with Sickle Cell Anemia
TL;DR: From a pediatric service with 151 to 165 admissions yearly for various problems associated with sickle cell anemia, the service has had to deal with only four instances of priapism in the last five years.