Profile of wound healing process induced by allantoin
Lorena Ulhôa Araújo,Andrea Grabe-Guimarães,Vanessa Carla Furtado Mosqueira,Cláudia Martins Carneiro,Neila Márcia Silva-Barcellos +4 more
TLDR
The histological wound healing profile induced by allantoin in rats is shown for the first time and it is demonstrated that it is able to ameliorate and fasten the reestablishment of the normal skin.Abstract:
Purpose: To evaluate and characterize the wound healing process profile induced by allantoin incorporated in soft lotion oil/water emulsion using the planimetric and histological methods. Methods: Female Wistar rats (n=60) were randomly assigned to 3 experimental groups: (C) control group-without treatment; (E) group treated with soft lotion O/W emulsion excipients; (EA) group treated with soft lotion O/W emulsion containing allantoin 5%. The emulsions either containing or not allantoin were topically administered for 14 days and the wound area was evaluated by planimetry and by qualitative and quantitative histological analysis of open wound model. Results: The data which were obtained and analyzed innovate by demonstrating, qualitatively and quantitatively, by histological analysis, the profile of healing process induced by allantoin. The results suggest that the wound healing mechanism induced by allantoin occurs via the regulation of inflammatory response and stimulus to fibroblastic proliferation and extracellular matrix synthesis. Conclusion: This work show, for the first time, the histological wound healing profile induced by allantoin in rats and demonstrated that it is able to ameliorate and fasten the reestablishment of the normal skin.read more
Citations
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Skin wound healing and phytomedicine: a review.
TL;DR: The common beneficial medicinal plants in the management of skin wounds are reviewed with an attempt to explain their mechanisms.
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Chitosan-alginate membranes accelerate wound healing
Guilherme Ferreira Caetano,Marco Andrey Cipriani Frade,Thiago Antônio Moretti de Andrade,Marcel Nani Leite,Cecilia Zorzi Bueno,Ângela Maria Moraes,João Tadeu Ribeiro-Paes +6 more
TL;DR: Chitosan-alginate membrane modulated the inflammatory phase, stimulated fibroplasia and collagenesis, accelerating wound healing process in rats, and showed faster reepithelialization on 7(th) day than SL group, although similar in other days.
Natural wound healing and bioactive natural products
TL;DR: The present review was designed to elaborate the cellular and molecular targets for plant secondary metabolites that target the various aspects of wound repair process.
Journal ArticleDOI
Effect of Semisolid Formulation of Persea Americana Mill (Avocado) Oil on Wound Healing in Rats
Ana Paula Ligeiro de Oliveira,Eryvelton de Souza Franco,Rafaella Rodrigues Barreto,Daniele Pires Cordeiro,Rebeca Gonçalves de Melo,Camila Maria Ferreira de Aquino,Antonio Alfredo Rodrigues e Silva,Paloma Lys de Medeiros,Teresinha Gonçalves da Silva,Alexandre José da Silva Góes,Maria Bernadete de Sousa Maia +10 more
TL;DR: In this article, the wound-healing activity of a semisolid formulation of avocado oil, SSFAO 50%, or avocado oil in natura, on incisional and excisional cutaneous wound models in Wistar rats was evaluated.
Journal ArticleDOI
Effect of allantoin on experimentally induced gastric ulcers: Pathways of gastroprotection.
Dayane Moreira da Silva,José Luís Rodrigues Martins,Danillo Ramos de Oliveira,Iziara Ferreira Florentino,Daiany Priscilla Bueno da Silva,Fernanda Cristina Alcântara dos Santos,Elson Alves Costa +6 more
TL;DR: It is demonstrated for the first time that allantoin possesses gastroprotective activity through anti‐inflammatory, anti‐oxidative, antisecretory, and cytoprotective mechanisms.
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