Prognosis and treatment of FOLFOX therapy related interstitial pneumonia: a plea for multimodal immune modulating therapy in the respiratory insufficient patient.
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TLDR
Oncologists and critical care specialists are urged to limit their interventions to the discontinuation of chemotherapy, artificial ventilation, corticosteroids and glutathione replenishment and to consider the gradual introduction of additional immune-modulating agents whenever life-threatening respiratory symptoms in oxaliplatin-treated patients do not subside.Citations
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Metastasis is impaired by endothelial-specific Dll4 loss-of-function through inhibition of epithelial-to-mesenchymal transition and reduction of cancer stem cells and circulating tumor cells
Liliana Mendonça,Liliana Mendonça,Alexandre Trindade,Catarina Carvalho,Jorge Correia,Marina Badenes,Marina Badenes,Joana Gigante,Joana Gigante,Antonio Duarte +9 more
TL;DR: The results suggest that endothelial Dll4/Notch-function mediates tumor hypoxia-driven increase of EMT and appears to constitute a promising target to prevent metastasis.
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Interstitial pneumonia induced by cyclophosphamide: A case report and review of the literature
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Dynamic impact of inflammation-based indices in colorectal cancer patients receiving FOLFOX-based chemotherapy.
Yong Tao,Danping Yuan,Hongshuang Pang,Hongbiao Wu,Dongfang Liu,Ningning Jin,Ningning Wu,Jianming Qiu,Yuepeng Cao +8 more
TL;DR: Evaluating this index can accurately predict the clinical treatment outcomes after chemotherapy, and was a significant prognostic predictor for CRC patients who received FOLFOX-based chemotherapy.
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CT features of lung metastases from pancreatic adenocarcinoma: Correlation with histopathologic findings
Mathilde Aissaoui,Audrey Lupo,Romain Coriat,Benoit Terris,Souhail Bennani,Guillaume Chassagnon,Marie-Pierre Revel +6 more
TL;DR: In this article, the authors evaluated the prevalence of an atypical, alveolar presentation of pulmonary metastases from pancreatic adenocarcinoma (PDAC) on computed tomography (CT) and to correlate CT features with those obtained at histopathologic analysis.
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Oxaliplatin-induced Pulmonary Toxicity: A Rare but Serious Complication
TL;DR: Two cases of pulmonary toxicity in patients with metastatic colorectal cancer treated with FOLFOX are described and the literature regarding oxaliplatin-induced pulmonary toxicity is reviewed.
References
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Journal ArticleDOI
Oxaliplatin: A review of preclinical and clinical studies
TL;DR: Its single agent and combination therapy data in ovarian cancer confirm its non-cross resistance with cisplatin/carboplatin and topoisomerase I inhibitors, and the absence of hematologic dose-limiting toxicity have made oxaliplatin an attractive compound for combinations.
Book ChapterDOI
Epidemiology of stomach cancer.
TL;DR: While some factors related to diet and food preservation, such as high intake of salt-preserved foods and dietary nitrite or low intake of fruit and vegetables, are likely to increase the risk of stomach cancer, the quantitative impact of many dietary factors remains uncertain, partly due to limitations of exposure assessment and control for confounding factors.
Journal Article
Cellular and molecular pharmacology of oxaliplatin.
TL;DR: The differences between oxaliplatin and cisplatin in terms of their spectrum of activity and adduct formation are described and molecular and cellular experimental data that potentially explain them are discussed, with particular emphasis on the differential role of DNA repair mechanisms.
Journal ArticleDOI
Interstitial Lung Disease Induced by Drugs and Radiation
TL;DR: The diagnosis of drug-induced ILD (DI-ILD) essentially rests on the temporal association between exposure to the drug and the development of pulmonary infiltrates, and the histopathological features of DI-ILD are generally consistent, rather than suggestive or specific to thedrug etiology.
Journal Article
Epidemiology of stomach cancer
TL;DR: It seems likely that, when the device has proved itself electronically reliable, a unit of this design may well prove the ideal method of pacing the heart when stable atrial rhythm is present with complete heart block, thus truly abolishing heart block.