Journal ArticleDOI
Prognostic Factors in High-Grade Osteosarcoma of the Extremities or Trunk: An Analysis of 1,702 Patients Treated on Neoadjuvant Cooperative Osteosarcoma Study Group Protocols
Stefan S. Bielack,Beate Kempf-Bielack,Günter Delling,G. Ulrich Exner,Silke Flege,Knut Helmke,Rainer Kotz,Mechthild Salzer-Kuntschik,M. Werner,Winfried Winkelmann,Andreas Zoubek,Heribert Jürgens,Kurt Winkler +12 more
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Axial tumor site, male sex, and a long history of symptoms were associated with poor response to chemotherapy in univariate and multivariate analysis.Abstract:
PURPOSE: To define prognostic factors for response and long-term outcome for a wide spectrum of osteosarcomas, extending well beyond those of the typical young patient with seemingly localized extremity disease. PATIENTS AND METHODS: A total of 1,702 consecutive newly diagnosed patients with high-grade osteosarcoma of the trunk or limbs registered into the neoadjuvant studies of the Cooperative Osteosarcoma Study Group before July 1998 were entered into an analysis of demographic, tumor-related, and treatment-related variables, response, and survival. The intended therapeutic strategy included preoperative and postoperative chemotherapy with multiple agents as well as surgery of all operable lesions. RESULTS: Axial tumor site, male sex, and a long history of symptoms were associated with poor response to chemotherapy in univariate and multivariate analysis. Actuarial 10-year overall and event-free survival rates were 59.8% and 48.9%. Among the variables assessable at diagnosis, patient age (actuarial 10-y...read more
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Journal ArticleDOI
Intercalary allograft reconstructions following resection of primary bone tumors : A nationwide multicenter study
M. P. A. Bus,P. D. S. Dijkstra,M. A. J. van de Sande,Antonie H. M. Taminiau,H.W.B. Schreuder,Paul C Jutte,I.C.M. van der Geest,Gerard R. Schaap,Jos A. M. Bramer +8 more
TL;DR: High complication rates and considerable failure rates for the use of intercalary allografts are reported; complications primarily occurred in the first years after surgery, but some occurred much later after surgery.
Journal ArticleDOI
CD8 + /FOXP3 + -ratio in osteosarcoma microenvironment separates survivors from non-survivors: a multicenter validated retrospective study.
Benedikt Fritzsching,Joerg Fellenberg,Linda Moskovszky,Zoltán Sápi,Tibor Krenács,Isidro Machado,Johannes Poeschl,Burkhard Lehner,Miklós Szendröi,Antonio Llombart Bosch,Ludger Bernd,Monika Csóka,Gunhild Mechtersheimer,Volker Ewerbeck,Ralf Kinscherf,Pierre Kunz +15 more
TL;DR: Intratumoral CD8+/FOXP3+-ratio in pretreatment biopsies separates patients with prolonged survival from non-survivors in osteosarcoma, and demonstrates independence from current prognostic factors including metastasis and response to neoadjuvant chemotherapy.
Journal ArticleDOI
Osteosarcoma of the Pelvis: Outcome Analysis of Surgical Treatment
TL;DR: Patients who presented with metastasis had a worse survival than patients who had no evidence of metastasis at presentation, and aggressive therapy may be justified.
Journal ArticleDOI
Orthopedic surgery options for the treatment of primary osteosarcoma.
TL;DR: No difference in survival has been shown between amputations and adequately performed limb-salvaging procedures, and amputation remains a valid procedure in selected cases of osteosarcoma in most parts of the world.
Journal ArticleDOI
Advances in the management of osteosarcoma.
TL;DR: Osteosarcoma, a bone cancer most commonly seen in adolescents and young adults, is usually a high-grade malignancy characterized by a very high risk for the development of pulmonary metastases, with a very limited number of active agents available.
References
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Book ChapterDOI
Nonparametric Estimation from Incomplete Observations
Edward L. Kaplan,Paul Meier +1 more
TL;DR: In this article, the product-limit (PL) estimator was proposed to estimate the proportion of items in the population whose lifetimes would exceed t (in the absence of such losses), without making any assumption about the form of the function P(t).
Book ChapterDOI
Regression Models and Life-Tables
TL;DR: The analysis of censored failure times is considered in this paper, where the hazard function is taken to be a function of the explanatory variables and unknown regression coefficients multiplied by an arbitrary and unknown function of time.
Journal Article
Evaluation of survival data and two new rank order statistics arising in its consideration.
Journal ArticleDOI
Underrepresentation of patients 65 years of age or older in cancer-treatment trials.
TL;DR: There is substantial under representation of patients 65 years of age or older in studies of treatment for cancer, and the reasons should be clarified, and policies adopted to correct this underrepresentation.