Journal ArticleDOI
Prognostic Factors in High-Grade Osteosarcoma of the Extremities or Trunk: An Analysis of 1,702 Patients Treated on Neoadjuvant Cooperative Osteosarcoma Study Group Protocols
Stefan S. Bielack,Beate Kempf-Bielack,Günter Delling,G. Ulrich Exner,Silke Flege,Knut Helmke,Rainer Kotz,Mechthild Salzer-Kuntschik,M. Werner,Winfried Winkelmann,Andreas Zoubek,Heribert Jürgens,Kurt Winkler +12 more
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TLDR
Axial tumor site, male sex, and a long history of symptoms were associated with poor response to chemotherapy in univariate and multivariate analysis.Abstract:
PURPOSE: To define prognostic factors for response and long-term outcome for a wide spectrum of osteosarcomas, extending well beyond those of the typical young patient with seemingly localized extremity disease. PATIENTS AND METHODS: A total of 1,702 consecutive newly diagnosed patients with high-grade osteosarcoma of the trunk or limbs registered into the neoadjuvant studies of the Cooperative Osteosarcoma Study Group before July 1998 were entered into an analysis of demographic, tumor-related, and treatment-related variables, response, and survival. The intended therapeutic strategy included preoperative and postoperative chemotherapy with multiple agents as well as surgery of all operable lesions. RESULTS: Axial tumor site, male sex, and a long history of symptoms were associated with poor response to chemotherapy in univariate and multivariate analysis. Actuarial 10-year overall and event-free survival rates were 59.8% and 48.9%. Among the variables assessable at diagnosis, patient age (actuarial 10-y...read more
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Journal ArticleDOI
Upper Extremity Considerations for Oncologic Surgery
Justin C. Wong,John Abraham +1 more
TL;DR: With advances in chemotherapy, radiotherapy, tumor imaging, and surgical reconstructive options, limb salvage surgery is estimated to be feasible in 95% of extremity bone or soft tissue sarcomas.
Journal ArticleDOI
High Expression of XRCC6 Promotes Human Osteosarcoma Cell Proliferation through the β-Catenin/Wnt Signaling Pathway and Is Associated with Poor Prognosis
TL;DR: Findings indicate that XRCC6 exerts tumor-promoting effects for OS through β-catenin/Wnt signaling pathway and may serve as a novel therapeutic target for OS patients.
Journal ArticleDOI
Osteosarcoma presentation stages at a tumour unit in South Africa
Nando Ferreira,Leonard C Marais +1 more
TL;DR: The great majority of patients referred to the tumour unit present with locally advanced or metastatic disease, which limits treatment options and adversely affects survival.
Journal ArticleDOI
Conditioned media from mouse osteosarcoma cells promote MC3T3-E1 cell proliferation using JAKs and PI3-K/Akt signal crosstalk.
Kanji Mori,Frédéric Blanchard,Frédéric Blanchard,Céline Charrier,Céline Charrier,Séverine Battaglia,Séverine Battaglia,Kosei Ando,Laurence Duplomb,Laurence Duplomb,Leonard D. Shultz,Françoise Rédini,Françoise Rédini,Dominique Heymann,Dominique Heymann +14 more
TL;DR: Determination of the specific factor(s) responsible for JAKs and PI3‐K/Akt signal crosstalk that results in up‐regulated preosteoblast proliferation will offer new insight into the pathology of osteosarcoma as well as other bone‐related diseases.
Journal ArticleDOI
Outcome of Pelvic Bone Sarcomas in Children.
TL;DR: Attaining a wide surgical margin should be the aim of treatment for all children with primary bone tumors of the pelvis, and in ES, chemotherapy response has a greater influence on disease free and overall survival.
References
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Book ChapterDOI
Nonparametric Estimation from Incomplete Observations
Edward L. Kaplan,Paul Meier +1 more
TL;DR: In this article, the product-limit (PL) estimator was proposed to estimate the proportion of items in the population whose lifetimes would exceed t (in the absence of such losses), without making any assumption about the form of the function P(t).
Book ChapterDOI
Regression Models and Life-Tables
TL;DR: The analysis of censored failure times is considered in this paper, where the hazard function is taken to be a function of the explanatory variables and unknown regression coefficients multiplied by an arbitrary and unknown function of time.
Journal Article
Evaluation of survival data and two new rank order statistics arising in its consideration.
Journal ArticleDOI
Underrepresentation of patients 65 years of age or older in cancer-treatment trials.
TL;DR: There is substantial under representation of patients 65 years of age or older in studies of treatment for cancer, and the reasons should be clarified, and policies adopted to correct this underrepresentation.