Journal ArticleDOI
Pronounced Reduction of Total Neuron Number in Mediodorsal Thalamic Nucleus and Nucleus Accumbens in Schizophrenics
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TLDR
Using a new and unbiased stereological technique, the total numbers of neuron and glial cells in the mediodorsal thalamic nucleus and the nucleus accumbens were found to be significantly reduced in schizophrenic patients compared with controls.Abstract:
• Using a new and unbiased stereological technique, the total numbers of neuron and glial cells in the mediodorsal thalamic nucleus and the nucleus accumbens were found to be significantly reduced in schizophrenic patients compared with controls. The total neuron and glial cell number in the ventral pallidum and in the basolateral nucleus of amygdala did not differ in the two groups.read more
Citations
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Schizophrenia genes, gene expression, and neuropathology: on the matter of their convergence.
TL;DR: This review critically summarizes the neuropathology and genetics of schizophrenia, the relationship between them, and speculates on their functional convergence via an influence upon synaptic plasticity and the development and stabilization of cortical microcircuitry.
Journal ArticleDOI
The neuropathology of schizophrenia. A critical review of the data and their interpretation.
TL;DR: Functional imaging data indicate that the pathophysiology of schizophrenia reflects aberrant activity in, and integration of, the components of distributed circuits involving the prefrontal cortex, hippocampus and certain subcortical structures.
Journal ArticleDOI
Decreased dendritic spine density on prefrontal cortical pyramidal neurons in schizophrenia.
Leisa A. Glantz,David A. Lewis +1 more
TL;DR: This region- and disease-specific decrease in dendritic spine density on dorsolateral prefrontal cortex layer 3 pyramidal cells is consistent with the hypothesis that the number of cortical and/or thalamic excitatory inputs to these neurons is altered in subjects with schizophrenia.
Journal ArticleDOI
“Cognitive Dysmetria” as an Integrative Theory of Schizophrenia: A Dysfunction in Cortical-Subcortical-Cerebellar Circuitry?
TL;DR: A model that implicates connectivity among nodes located in prefrontal regions, the thalamic nuclei, and the cerebellum is developed that produces "cognitive dysmetria", difficulty in prioritizing, processing, coordinating, and responding to information in schizophrenia.
Journal ArticleDOI
The reduced neuropil hypothesis: a circuit based model of schizophrenia
TL;DR: It is proposed that a reduction in interneuronal neuropil in the prefrontal cortex is a prominent feature of cortical pathology in schizophrenia and growing evidence for this view is reviewed from reports of altered neuronal density and immunohistochemical markers in various cortical regions.
References
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The unbiased estimation of number and sizes of arbitrary particles using the disector
TL;DR: A three‐dimensional counting rule and its integral test system, the disector, for obtaining unbiased estimates of the number of arbitrary particles in a specimen is presented.
Journal ArticleDOI
The new stereological tools: disector, fractionator, nucleator and point-sampled intercepts and their use in pathological research and diagnosis
H. J. G. Gundersen,P. V. Bagger,Thomas Fichtner Bendtsen,S.M. Evans,L. Korbo,Niels Marcussen,Arne Møller,Karsten Nielsen,Jens R. Nyengaard,Bente Pakkenberg,Sørensen Fb,A. Vesterby,Mark J. West +12 more
TL;DR: The new stereological methods for correct and efficient sampling and sizing of cells and other particles are reviewed and practical examples of applications to a wide range of histological entities are illustrated.
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Cerebral ventricular size and cognitive impairment in chronic schizophrenia
TL;DR: By comparison with age-matched controls in employment, 17 institutionalised schizophrenic patients were shown by computerised axial tomography of the brain to have increased cerebral ventricular size.