Journal ArticleDOI
Properties, function and origin of the alveolar lining layer.
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TLDR
Equally stable foam is found in the bronchi of an animal the respiratory movements of which have been paralysed and into the trachea of which a mixture of oxygen and ammonia gas has been insufflated for one or two hours.Abstract:
IN acute lung œdema in the rabbit, fluid a ad foam are found in the trachea. This foam has an altogether peculiar property, in that it is unaffected by silicone anti-foams; these rapidly destroy the foams produced by shaking œdema fluid or blood serum with air. Equally stable foam is found in the bronchi of an animal the respiratory movements of which have been paralysed and into the trachea of which a mixture of oxygen and ammonia gas has been insufflated for one or two hours; similar foams are obtained from healthy lung by cutting and squeezing under water, or after introduction of saline into the trachea. The stability of such foams is due to an insoluble surface layer on the bubbles; this layer can be attacked by pancreatin or by trypsin.read more
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Book ChapterDOI
Protein and lipid interactions in lung surfactant monolayers
TL;DR: In this paper, the phase behavior of lung surfactant protein SP-B and its amino terminus (SP-Bl_25) was studied and the authors found that the peptide retained most of the native activity of the protein, which may lead cheaper and more effective synthetic replacement formulations.
Book ChapterDOI
Respiratory Mechanics: Principles, Utility and Advances
A. R. Carvalho,W. A. Zin +1 more
TL;DR: Pulmonary gas exchange requires a continuous flow of fresh gas and blood through the alveoli and alveolar capillaries, and the external forces must overcome the impedance of the lung and chest wall, the two components of the respiratory system.
Dissertation
Study of pH-dependent misfolding of surfactant protein C using state-of-the-art molecular modelling techniques
TL;DR: The aim of this work is to contribute towards reducing the computational time of the analysis of SP-C by studying the Misfolding by Molecular Modelling Methods and Statistical Mechanics.
Dissertation
Surfactant metabolism in the newborn : The impact of ventilation strategy and lung disease
TL;DR: This investigation is one of the first to describe normal surfactant turnover in vivo in term infants using a novel stable isotope technique and experimentally test the hypothesis, that surfactan administration followed by spontaneous breathing improves the treatment response.
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