Journal ArticleDOI
Properties, function and origin of the alveolar lining layer.
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Equally stable foam is found in the bronchi of an animal the respiratory movements of which have been paralysed and into the trachea of which a mixture of oxygen and ammonia gas has been insufflated for one or two hours.Abstract:
IN acute lung œdema in the rabbit, fluid a ad foam are found in the trachea. This foam has an altogether peculiar property, in that it is unaffected by silicone anti-foams; these rapidly destroy the foams produced by shaking œdema fluid or blood serum with air. Equally stable foam is found in the bronchi of an animal the respiratory movements of which have been paralysed and into the trachea of which a mixture of oxygen and ammonia gas has been insufflated for one or two hours; similar foams are obtained from healthy lung by cutting and squeezing under water, or after introduction of saline into the trachea. The stability of such foams is due to an insoluble surface layer on the bubbles; this layer can be attacked by pancreatin or by trypsin.read more
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Pulmonary surfactants and their role in pathophysiology of lung disorders
TL;DR: The biochemical, physiological, developmental and clinical aspects of pulmonary surfactant are presented in this article to understand the pathophysiological mechanisms of these diseases.
Journal ArticleDOI
Continuous Positive Airway Pressure and Surfactant
TL;DR: The history, current knowledge and techniques of CPAP and surfactant are discussed and INSURE (INtubation SURfactant Extubation) can be given during nCPAP treatment further reducing need for mechanical ventilation.
Journal ArticleDOI
Function and Composition of Pulmonary Surfactant and Surfactant-Derived Fatty Acid Profiles Are Altered in Young Adults With Cystic Fibrosis
Keith C. Meyer,Anuja Sharma,Raymond R. Brown,Mark Weatherly,Fernando R. Moya,June R. Lewandoski,Jerry J. Zimmerman +6 more
TL;DR: Altered phospholipid-to-protein ratios and phospholIPid subclasses, altered surfactant-derived fatty acid profiles, high minimal surface tension, and decreased association of SP-A with lipid components of isolated surfacts indicate that surfactants are considerably altered and dysfunctional in lower respiratory tract secretions of CF patients.
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The Adult Respiratory Distress Syndrome
Philip C. Hopewell,John Murray +1 more
TL;DR: Pulmonary function may be compromised by fat embolism, high concentrations of oxygen, long term positive ressure respiratory support, intracranial injury, extra-thoracic trauma, and shock of several etiologies.
Journal ArticleDOI
Controlled trial of artificial surfactant to prevent respiratory distress syndrome.
TL;DR: There appeared to be a trend towards improved survival in treated babies of 27-29 weeks' gestation, and there were no significant differences in mortality or in the incidence or severity of respiratory distress syndrome between the surfactant-treated and control groups.
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