Journal ArticleDOI
Propylthiouracil induced C-ANCA positive agranulocytosis complicating Graves’ thyrotoxicosis in pregnancy
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TLDR
Second trimester subtotal thyroidectomy was safe and effective in treating this pregnant patient’s thyrotoxicosis and highlights the association of propylthiouracil induced ANCA positivity and agranulocytosis.Abstract:
Background
Thionamide induced agranulocytosis is associated with the presence of anti-neutrophil cytoplasmic antibodies (ANCA) in some patients. This poses a particular challenge when it occurs during pregnancy.read more
Citations
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Journal ArticleDOI
Side effects of anti-thyroid drugs and their impact on the choice of treatment for thyrotoxicosis in pregnancy.
Peter Taylor,Bijay Vaidya +1 more
TL;DR: More evidence is still needed in defining the relative risks between CBZ/MMI and PTU of major congenital abnormalities and severe liver injury in pregnancy, and studies are also needed to establish the suitability of recent management suggestions in switching from PTU to CBZ /MMI after the first trimester.
Journal ArticleDOI
Antineutrophil cytoplasmic antibodies, autoimmune neutropenia, and vasculitis.
TL;DR: ANCA is associated with autoimmune neutropenia, but systemic vasculitis rarely occurs in association with ANCA and neutropensia, and the interaction between neutrophils and ANCA may provide insight into understanding both autoimmune neutopenia and AAV.
Journal ArticleDOI
Patient Knowledge of Antithyroid Drug-Induced Agranulocytosis
Jonah Robinson,Max Richardson,Janis Hickey,Andy James,Simon H. S. Pearce,S. G. Ball,Richard Quinton,Margaret A. Morris,Margaret Miller,Petros Perros +9 more
TL;DR: Inadequate knowledge about agranulocytosis among patients receiving antithyroid drug treatment is common and the available information on the internet is variable and inconsistent.
Journal ArticleDOI
Safety of antithyroid drugs in pregnancy: update and therapy implications.
TL;DR: This review provides an update on the safety of antithyroid drugs in pregnancy, focusing on the most serious concerns of severe liver disease and congenital anomalies.
Journal ArticleDOI
Propylthiouracil-induced agranulocytosis in the third trimester of pregnancy.
TL;DR: The proximity to term in the third trimester makes expectant management an attractive approach when maternal thyroid indices are stable, allowing for a choice of postpartum therapies without the worry of fetal implications, but this strategy carries risks, and thyroidectomy in thethird trimester can be a safe alternative.
References
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Journal ArticleDOI
Case records of the Massachusetts General Hospital.
Journal ArticleDOI
The Regulation of Thyroid Function in Pregnancy: Pathways of Endocrine Adaptation from Physiology to Pathology
TL;DR: A global view of thyroidal economy in pregnancy and the hypothalamic-pituitary-thyroid axis and the role of hCG are presented.
Journal ArticleDOI
Weekly clinicopathological exercises
Robert E. Scully,Eugene J. Mark,William F. McNeely,Jo-Anne O. Shepard,Sally H. Ebeling,Stacey M. Ellender,Christine C. Peters +6 more
Journal ArticleDOI
Thyrotoxicosis complicating pregnancy
Lowell E. Davis,Lowell E. Davis,Michael J. Lucas,Michael J. Lucas,Gary D.V. Hankins,Gary D.V. Hankins,Micki Roark,Micki Roark,F. Gary Cunningham,F. Gary Cunningham +9 more
TL;DR: Aggressive medical therapy seems appropriate, especially when pregnancy is advanced, because there were minimal adverse effects from therapy described here and because uncontrolled thyrotoxicosis caused significant maternal and perinatal morbidity.
Journal ArticleDOI
Antithyroid drug-induced agranulocytosis: special reference to normal white blood cell count agranulocytosis.
Junichi Tajiri,Shiro Noguchi +1 more
TL;DR: It is concluded that the leukocyte differentiated count and not only routine white blood count was critically important for the correct diagnosis of antithyroid drug-induced agranulocytosis in patients with Graves' disease.