Showing papers in "Seminars in Arthritis and Rheumatism in 2011"

TL;DR: 4 types of formal consensus methods used in the health field and their applications in rheumatology are discussed: the Delphi method, Nominal Group Technique, RAND/UCLA Appropriateness Method, and National Institutes of Health consensus development conference.

TL;DR: A meta-analysis of relevant publications found that NP syndromes were estimated to exist in more than half of SLE patients, and the most prevalent manifestations were headache, mood disorders, and cognitive dysfunction.

TL;DR: There is enough published experience to suggest that TNF blockade represents an important therapeutic advancement for patients with severe and resistant, or intolerant, to standard immunosuppressive regimens BD.

TL;DR: 97% of cases of ILD associated with biologic agents were associated with agents blocking tumor necrosis factor-α, a cytokine that has been implicated in the pathophysiology of pulmonary fibrosis, and drug-induced ILD had a poor prognosis.

TL;DR: Interleukin-1 targeting drugs may be good candidates when looking for an alternative or supplementary treatment to colchicine, and the need for controlled trials to further evaluate the safety and efficacy of interleukIn-1 antagonists in FMF patients is highlighted.

TL;DR: PVNS occurs in young adults, mainly in the knee joint; joint pain and effusion with hemarthrosis are the most frequent signs and the usefulness of isotopic synoviorthesis remains to be confirmed.

TL;DR: Cross-sectional data point to a potential role of vitamin D in autoimmune disease prevention, but prospective interventional evidence in humans is still lacking and interventional trials have investigated whether vitamin D affects human autoimmune disease risk.

TL;DR: The results indicate that both grayscale US and PD findings indicative of enthesopathy were more frequent in patients with psoriasis, suggesting the US ability to detect signs of subclinical entheseal involvement at lower limbs should be the object of longitudinal investigations to define its value in predicting the clinical onset of psoriatic arthritis.

TL;DR: The observations support the current evidence base for an increased cardiovascular burden in RA and support the use of cIMT in observational studies in RA patients and determine its utility as a surrogate cardiovascular risk marker in RA in prospective studies.

TL;DR: Patients with primary Sjögren's syndrome have a 16-fold increased risk of developing lymphoma, and this risk increases with time, and Hypocomplementemia and lymphocytopenia at pSS diagnosis are the strongest predictors.

TL;DR: The prevalence of PN is relatively high in SLE and occurs more frequently in patients with central nervous system involvement and high SLE-disease activity index.

TL;DR: Uveitis occurs de novo under anti-TNF therapy mainly in spondyloarthropathies, but also in rheumatoid arthritis and juvenile idiopathic arthritis patients and more frequently under etanercept.

TL;DR: The results suggest that prophylaxis against pyogenic infections should be routinely recommended for patients with PM/DM, including regular physical examination of lungs to depict aspiration pneumonia as well as risk factors of aspiration pneumonia.

TL;DR: An overview of the current state of imaging of synovitis in osteoarthritis (OA), looking at recent advances and controversies and focusing particularly on the application of ultrasound and magnetic resonance imaging in the assessment of the hand and knee joint is provided.

TL;DR: An epidemiologic change of PVO is suggested by a higher incidence of PPVO and the isolation of less virulent microorganisms among MCPVO.

TL;DR: Among community-dwelling elderly men, DISH prevalence is high, increases with age, and is positively associated with BMI and blood pressure.

TL;DR: Of the available bisphosphonates for osteoporosis, zoledronic acid has the highest probability of offering the best overall fracture protection, and is likely to show the greatest reduction in any fracture.

TL;DR: DKK-1 is a regulator of bone mass with increased expression linked to osteopenia and decreased expression to high bone mass and appears to actively participate in joint remodeling in animal models of arthritis, with increased levels related to bone resorption and decreased levels to new bone formation.

TL;DR: Overall cancer and mortality rates in patients with rheumatic diseases exposed to TNF antagonists are no higher than in the background Spanish population, however special attention should be paid to elderly patients, those with previous cancers, and patients treated with steroids.

TL;DR: TNF-alpha blocking therapy has a modest effect on TC and HDLc levels in RA patients with no significant overall effect on the atherogenic index.

TL;DR: Based on the evidence collated, immunosuppressants and biological therapies (except for daclizumab in Behçet and etanercept) may be effective in autoimmune uveitis and macular edema.

TL;DR: It is not clear whether TNF antagonists increase the incidence of demyelinating diseases in patients with rheumatic diseases, and differences between cases depending on the pharmacovigilance source could be explained by selective reporting bias outside registries.

TL;DR: Although a rheumatoid arthritis-like or a collapse arthropathy can be observed in SSc patients, arthropathies are less common than previously reported.

TL;DR: Evidence for the effectiveness of RTX as induction therapy in NPSLE is based solely on several case reports and noncontrolled trials, and the global analysis of these cases supports the off-label use of RTX in cases of severe refractory NPSle.

TL;DR: In PFAPA, MEFV is a modifier gene associated with an attenuated disease severity that may lead to subclinical inflammation in asymptomatic carriers and modify the phenotype of some inflammatory diseases.

TL;DR: Preliminary results from clinical and epidemiological studies suggest metabolic and inflammatory mechanisms play roles in the pathogenesis of OA and may also mediate the effects of obesity on OA.

TL;DR: Clinical and ultrasound evaluations of MCP and MTP joint synovitis in juvenile idiopathic arthritis are compared to determine the prevalence of predefined ultrasound abnormalities in JIA patients and healthy controls and ultrasonography is useful for monitoringsynovitis.

TL;DR: WOMAC normative values provide opportunity for benchmarking the health status of individuals with hip and knee osteoarthritis against their age- and gender-matched peers in the general population in both clinical practice and research.

TL;DR: Sulfamethoxazole/trimethoprim single strength can be used effectively as a primary prophylaxis against PCP in high-risk CTD patients and only mild ADR developed at this dosage.

TL;DR: There is a relationship between radiographic sacroiliitis, spinal fusion, and hip involvement in patients with AS and damage to the spine and hip seen radiographically can contribute to functional impairment.