Journal ArticleDOI
Prostaglandin D2 inhibits the aggregation of human platelets
TLDR
Prostaglandin D2, heretofore considered to be biologically inactive, was found to be more than twice as potent as prostaglandsin E1 as an inhibitor of aggregation in human citrated platelet-rich plasma.About:
This article is published in Thrombosis Research.The article was published on 1974-09-01. It has received 213 citations till now. The article focuses on the topics: Prostaglandin E2 receptor & Prostaglandin.read more
Citations
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Journal ArticleDOI
An enzyme isolated from arteries transforms prostaglandin endoperoxides to an unstable substance that inhibits platelet aggregation.
TL;DR: A balance between formation of anti- and pro-aggregatory substances by enzymes could also contribute to the maintenance of the integrity of vascular endothelium and explain the mechanism of formation of intra-arterial thrombi in certain physiopathological conditions.
Journal ArticleDOI
A lipid peroxide inhibits the enzyme in blood vessel microsomes that generates from prostaglandin endoperoxides the substance (prostaglandin X) which prevents platelet aggregation
TL;DR: Investigation of microsomes from arterial wall or fundus of stomach with platelet-rich plasma under various conditions shows that the enzyme which generates PGX can utilize endoperoxides liberated from platelets or added to the cuvette, thereby preventing, interrupting or reversing the process of platelet aggregation.
Journal ArticleDOI
Cancer metastasis. Organ colonization and the cell-surface properties of malignant cells.
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Selective release of archidonic acid from the phospholipids of human platelets in response to thrombin.
T K Bills,J B Smith,M J Silver +2 more
TL;DR: The present studies show that human platelets contain phospholipase A2 activities that preferentially release arachidonic acid, and one of these activities specifically utilizes 1-acyl-2-arachidonyl-phosphatidyl-choline, both of which are highly enriched with arachIDonic acid.
References
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Journal ArticleDOI
Aggregation of blood platelets by adenosine diphosphate and its reversal.
Journal ArticleDOI
Isolation and Structure of Two Prostaglandin Endoperoxides That Cause Platelet Aggregation
TL;DR: Platelet aggregation induced by thrombin was accompanied by release of material reducible by stannous chloride into prostaglandin F(2alpha), thus indicating the involvement of endogenous prostaglandsin endoperoxides in platelet aggregation.
Journal ArticleDOI
Isolation and properties of intermediates in prostaglandin biosynthesis
D.H. Nugteren,E. Hazelhof +1 more
TL;DR: The finding that prostaglandin R can be converted enzymatically into the biologically inactive prostaglandsin D in good yields, reveals a new pathway in prostag landin metabolism and postulates the key position of prostag Landin R as the first biologically active product formed from essential fatty acids.
Journal ArticleDOI
Detection and isolation of an endoperoxide intermediate in prostaglandin biosynthesis.
Mats Hamberg,Bengt Samuelsson +1 more
TL;DR: The smooth muscle-stimulating activity of the endoperoxide ester on the isolated rabbit aortas trip was 4- to 8-times higher than that of the methyl ester of prostaglandin E(2).
Journal ArticleDOI
Prostaglandins and related factors: xix. thin-layer chromatography of prostaglandins.
Krister Gréen,Bengt Samuelsson +1 more
TL;DR: In this paper, the authors described methods for separation of all known prostaglandins and some derivatives as free acids and methyl esters by thin-layer chromatography both on analytical and preparative scales.
Related Papers (5)
Thromboxanes: a new group of biologically active compounds derived from prostaglandin endoperoxides.
An enzyme isolated from arteries transforms prostaglandin endoperoxides to an unstable substance that inhibits platelet aggregation.
Isolation and properties of intermediates in prostaglandin biosynthesis
D.H. Nugteren,E. Hazelhof +1 more