The role of lipids in platelet function: with particular reference to the arachidonic acid pathway.
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This article is published in Journal of Lipid Research.The article was published on 1978-09-01 and is currently open access. It has received 339 citations till now. The article focuses on the topics: Arachidonic acid.read more
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Phospholipid methylation and biological signal transmission
Fusao Hirata,Julius Axelrod +1 more
TL;DR: The methylation of phospholipids is coupled to Ca2+ influx and the release of arachidonic acid, lysophosphatidylcholine, and prostaglandins, resulting in the generation of adenosine 3',5'-monophophate in many cell types, release of histamine in mast cells and basophils, mitogenesis in lymphocytes, and chemotaxis in neutrophils.
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Transcellular metabolism of neutrophil-derived leukotriene A4 by human platelets. A potential cellular source of leukotriene C4.
Jacques Maclouf,Robert C. Murphy +1 more
TL;DR: The data indicate that platelets can produce large amounts of LTC4 from neutrophil-derived LTA4 and suggest that such interactions may occur in vivo and that platelet contribution could be an important contribution to the generation of the biologically active L TC4.
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Eighth Gaddum Memorial Lecture. University of London Institute of Education, December 1980. Biological importance of prostacyclin.
TL;DR: Bioassay has provided crucial information on the role of the lungs in the removal of prostaglandin research, including their discovery (Goldblatt, 1933; von Euler, 1934), were made by bioassay procedures.
References
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Inhibition of prostaglandin synthesis as a mechanism of action for aspirin-like drugs
TL;DR: Experiments with guinea-pig lung suggest that some of the therapeutic effects of sodium salicylate and aspirin-like drugs are due to inhibition of the synthesis of prostaglandins.
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An enzyme isolated from arteries transforms prostaglandin endoperoxides to an unstable substance that inhibits platelet aggregation.
TL;DR: A balance between formation of anti- and pro-aggregatory substances by enzymes could also contribute to the maintenance of the integrity of vascular endothelium and explain the mechanism of formation of intra-arterial thrombi in certain physiopathological conditions.
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The pathogenesis of atherosclerosis (first of two parts).
Russell Ross,John A. Glomset +1 more
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Thromboxanes: a new group of biologically active compounds derived from prostaglandin endoperoxides.
TL;DR: Evidence is presented that the more unstable and major component of rabbit aorta contracting substance (RCS) formed in platelets and guinea pig lung is also thromboxane A2.
Book
Free radical mechanisms in tissue injury
TL;DR: This short review of free radicals discusses certain types of free radical, such as nitroxyl-radicals and free radicals stabilized by steric or derealization features, which are stable enough to be crystallised and stored at temperatures above 0°.