Journal ArticleDOI
Prostate Specific Antigen in the Staging of Localized Prostate Cancer: Influence of Tumor Differentiation, Tumor Volume and Benign Hyperplasia
Alan W. Partin,H. Ballentine Carter,Daniel W. Chan,Jonathan I. Epstein,Joseph E. Oesterling,Robert C. Rock,Jed P. Weber,Patrick C. Walsh +7 more
TLDR
Serum prostate specific antigen levels do not reflect tumor burden and pathological stage accurately in individual patients for 2 reasons: 1) the unpredictable contribution from the benign prostatic hyperplasia component of the gland and 2) the decreasing production of prostatespecific antigen by higher grade lesions as tumor volume increases.About:
This article is published in The Journal of Urology.The article was published on 1990-04-01. It has received 590 citations till now. The article focuses on the topics: PCA3 & Prostate cancer.read more
Citations
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Journal ArticleDOI
Measurement of prostate-specific antigen in serum as a screening test for prostate cancer.
William J. Catalona,Deborah S. Smith,Timothy L. Ratliff,Kathy M. Dodds,Douglas E. Coplen,Jerry J.J. Yuan,John A. Petros,Gerald L. Andriole +7 more
TL;DR: The combination of measurement of the serum PSA concentration and rectal examination, with ultrasonography performed in patients with abnormal findings, provides a better method of detecting prostate cancer thanrectal examination alone.
Journal ArticleDOI
Pathologic and clinical findings to predict tumor extent of nonpalpable (stage T1c) prostate cancer
TL;DR: Serum PSA level, PSA density, and needle biopsy pathologic findings are accurate predictors of tumor extent and it may be reasonable to follow up some patients whose tumors are most likely insignificant with serial PSA measurements and repeated biopsies.
Journal ArticleDOI
Prostate specific antigen: a critical assessment of the most useful tumor marker for adenocarcinoma of the prostate.
TL;DR: It is unlikely that PSA by itself will become an effective screening tool for the early diagnosis of prostate cancer, but if combined with digital rectal examination and/or transrectal ultrasound it may become a vital part of any early detection program.
Journal ArticleDOI
The Use of Prostate Specific Antigen, Clinical Stage and Gleason Score to Predict Pathological Stage in Men with Localized Prostate Cancer
Alan W. Partin,John Yoo,H. Ballentine Carter,Jay D. Pearson,Daniel W. Chan,Jonathan I. Epstein,Patrick C. Walsh +6 more
TL;DR: From these analyses probability plots and nomograms have been constructed to assist urologists in the preoperative prediction of final pathological stage for patients with clinically localized prostate cancer.
Journal ArticleDOI
Detection of organ-confined prostate cancer is increased through prostate-specific antigen-based screening.
TL;DR: Screening based on PSA identifies some men with prostate cancer who have a significantly increased proportion of organ-confined tumors compared with those detected through evaluation for an abnormal digital rectal examination alone.
References
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Journal ArticleDOI
Prostate-Specific Antigen as a Serum Marker for Adenocarcinoma of the Prostate
TL;DR: PSA is more sensitive than PAP in the detection of prostatic cancer and will probably be more useful in monitoring responses and recurrence after therapy, however, since both PSA and PAP may be elevated in benign prostatic hyperplasia, neither marker is specific.
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Prostate Specific Antigen in the Diagnosis and Treatment of Adenocarcinoma of the Prostate. II. Radical Prostatectomy Treated Patients
Thomas A. Stamey,John N. Kabalin,John E. McNeal,Iain M. Johnstone,Fuad S. Freiha,Elise A. Redwine,Norman Yang +6 more
TL;DR: No difference in preoperative or postoperative prostate specific antigen levels, cancer volume, seminal vesicle invasion or incidence of pelvic lymph node metastasis was seen, providing the first quantitative evidence that small amounts of capsular penetration may not be of biological or prognostic significance.
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Purification of a human prostate specific antigen
TL;DR: This report presents the first demonstration of the purification of a prostate‐specific antigen that does not represent prostatic acid phosphatase and shows a single protein band on analytical polyacrylamide gel electrophoresis and isoelectric focusing.
Journal ArticleDOI
Prostate Specific Antigen in the Preoperative and Postoperative Evaluation of Localized Prostatic Cancer Treated with Radical Prostatectomy
Joseph E. Oesterling,Daniel W. Chan,Jonathan I. Epstein,Allyn W. Kimball,Debra J. Bruzek,Robert C. Rock,Charles B. Brendler,Patrick C. Walsh +7 more
TL;DR: It is suggested that preoperative levels of prostate specific antigen are not sufficiently reliable to predict final pathological stage on an individual basis in patients with early prostatic cancer, and that the antigen is a sensitive tumor marker for the detection of residual disease after radical prostatectomy and subsequent recurrence of tumor on long-term followup.
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Prostatic Specific Antigen and Prostatic Acid Phosphatase in the Monitoring and Staging of Patients with Prostatic Cancer
TL;DR: It is concluded that prostatic specific antigen is an excellent serum tumor marker for monitoring patients with prostatic carcinoma and that it surpasses prostatic acid phosphatase in this regard.