Protection for the Hydroxyl Group, Including 1,2‐ and 1,3‐Diols
Peter G. M. Wuts,Theodora W. Greene +1 more
- pp 16-366
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The article was published on 2002-04-23. It has received 105 citations till now. The article focuses on the topics: Group (periodic table).read more
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Therapeutic agents useful for treating pain
TL;DR: In this paper, a 4-Tetrazolyl-4-phenylpiperidine (4-TTE)-compound was used for treating or preventing pain or diarrhea in an animal.
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Process for the synthesis of oligomeric compounds
Vasulinga T. Ravikumar,Muthiah Manoharan,Daniel C. Capaldi,Achim H. Krotz,Douglas L. Cole,Andrei Guzaev +5 more
TL;DR: In this paper, synthetic processes are provided wherein oligomeric compounds are prepared having phosphodiester, phosphorothioate, or other covalent linkages, and the oligomers have substantially reduced exocyclic adducts deriving from acrylonitrile or related contaminants.
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N,N,N-Trimethyl chitosan: An advanced polymer with myriad of opportunities in nanomedicine.
Abhijeet D. Kulkarni,Harun M. Patel,Sanjay J. Surana,Yogesh H. Vanjari,Veena S. Belgamwar,Chandrakantsing V. Pardeshi +5 more
TL;DR: The aim of this review is to bring the TMC into the limelight so as to appraise it as an attractive functional polymer for nanomedicine applications which is facing oversight by regulatory agencies and manufacturers.
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Challenges in evaluation of chitosan and trimethylated chitosan (TMC) as mucosal permeation enhancers: From synthesis to in vitro application.
TL;DR: The reported extent of the permeation enhancement and cell viability after chitosan or TMC treatment in intestinal and airway models is critically evaluated and it is concluded that the apparent discrepancies can be explained by differences in polymer structure, experimental conditions and in vitro models.
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Processes for the synthesis of oligonucleotide compounds
Muthiah Manoharan,Andrei Guzaev +1 more
TL;DR: In this paper, a method for the preparation of oligonucleotides having bioreversible phosphate blocking groups is described, where the oligon nucleotides are prepared utilizing amidite type chemistry wherein the biore reversible phosphorus protecting group is formed as an integral part of the amidite reagent.
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Protection of hydroxyl groups as tert-butyldimethylsilyl derivatives
E. J. Corey,A. Venkateswarlu +1 more
TL;DR: In this paper, the authors describe a group of ethers calleddimethyl-tert-butylsilyl, which are stable in water or alcohol bases under normal conditions and also stable to hydrogenolysis and mild chemical reduction.
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A new method for the deoxygenation of secondary alcohols
TL;DR: In this paper, a general synthesis of O-cycloalkyl thioesters has been developed which gives access to O-cycle-alkyl seleno-formates and selenobenzoates.
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4-Dialkylaminopyridines as Highly Active Acylation Catalysts. [New synthetic method (25)]
TL;DR: The synthesis of 4-dialkylaminopyridines can be accomplished in two steps starting from pyridine as discussed by the authors, and these derivatives are approximately 104 times more active when used as acylation catalysts.