Journal ArticleDOI
QbD based development of proliposome of lopinavir for improved oral bioavailability.
TLDR
Overall results of the study indicate that the proliposome offers advantages of enhanced oral bioavailability for poorly soluble LPV.Citations
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Liposomes for Enhanced Bioavailability of Water-Insoluble Drugs: In Vivo Evidence and Recent Approaches.
TL;DR: In vivo evidence for the improved BA of water-insoluble drugs using liposomes is focused on to resolve doubts raised concerning liposomal oral delivery and insight is provided by highlighting the approaches used for in vivo achievements.
Journal ArticleDOI
Quality by design (QbD) approaches in current pharmaceutical set-up
TL;DR: This review describes the elements, different design and tools of QbD as well as multidimensional applications ofQbD ranging from dosage form and method development to meeting latest regulatory requirements and will be useful for the optimization of complex drug delivery systems in the future.
Journal ArticleDOI
Solubility and bioavailability enhancement study of lopinavir solid dispersion matrixed with a polymeric surfactant - Soluplus
TL;DR: Sluplus matrixed extrudate improved the LPV bioavailability through three mechanisms: H-bond with LPV, micelle formation in water and P-gp inhibition in vivo.
Journal ArticleDOI
Insights on Oral Drug Delivery of Lipid Nanocarriers: a Win-Win Solution for Augmenting Bioavailability of Antiretroviral Drugs
TL;DR: The review will systematically envisage the impending benefits and future perspectives of different lipid nanocarriers used in oral delivery of antiretroviral drugs, including nanoemulsion, solid lipid nanoparticle, nanostructured lipid carriers, and so on.
Journal ArticleDOI
A quality by design approach for the development of lyophilized liposomes with simvastatin
TL;DR: The design space for lyo-LCL-SIM was determined, in which the established quality requirements of the product are met, provided that the risk factors vary within the established limits.
References
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Journal ArticleDOI
Goodman and Gilman's the Pharmacological Basis of Therapeutics
William H. Stigelman,Pharm D. +1 more
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A review on phospholipids and their main applications in drug delivery systems
TL;DR: Five types of carriers based on phospholipids are introduced, including liposomes, intravenous lipid emulsions, micelles, drug-phospholipid complexes and cochleates, to introduce their applications in drug delivery systems.
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Transfersomes—A Novel Vesicular Carrier for Enhanced Transdermal Delivery: Development, Characterization, and Performance Evaluation
TL;DR: It is concluded from the study that complex lipid molecules, transfersomes, can increase the transdermal flux, prolong the release, and improve the site specificity of bioactive molecules.
Journal ArticleDOI
Impact of excipients on the absorption of P-glycoprotein substrates in vitro and in vivo.
TL;DR: Improved everted gut sac technique was used to screen excipients for their ability to enhance the absorption of digoxin and celiprolol in vitro and in vivo, showing that many excipient/surfactants can modify the pharmacokinetics of orally administered drugs that are P-gp substrates.