Journal ArticleDOI
Quantitative gas chromatography of prostaglandin E1 at the nanogram level: Use of deuterated carrier and multiple-ion analyzer
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This article is published in Analytical Biochemistry.The article was published on 1970-11-01. It has received 141 citations till now. The article focuses on the topics: Gas chromatography & Mass spectrometry.read more
Citations
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Journal ArticleDOI
Inhibition of prostaglandin synthesis in man.
TL;DR: The metabolite was determined in human urine by a method based on the use of the bis (O- 2 H 3 -methyloxime) derivative of dimethyl 7α-hydroxy-5,11-diketotetranor-prostane-1,16-dioate as internal standard and determination of the ratio between unlabeled and deuterium-labeled molecules by multiple-ion analysis.
Journal ArticleDOI
Simultaneous measurement of endogenous and deuterium-labeled tracer variants of choline and acetylcholine in subpicomole quantities by gas chromatography-mass spectrometry.
TL;DR: A method is described for the simultaneous analysis of endogenous and d 4 -labeled tracer variants of choline and acetylcholine by a gas chromatograph/mass spectrometer system operated in the specific ion detection mode.
Journal ArticleDOI
Studies with Deuterated Drugs
Book ChapterDOI
Prostaglandins (Eicosanoids) and Their Role in Ectothermic Organisms
T. Mustafa,K. C. Srivastava +1 more
TL;DR: The eicosanoid family includes PGs, thromboxanes (TXs), hydroperoxy- and hydroxyeicosatetraenoic acids (HPETEs and HETEs), the leukotrienes (LTs), and lipoxins (LXs).
References
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Journal ArticleDOI
Mass fragmentography: Identification of chlorpromazine and its metabolites in human blood by a new method
TL;DR: Chlorpromazine and some of its metabolites have been identified in human blood with the combination of gas chromatography and mass spectrometry and a new method, mass fragmentography, based upon a continuous recording of up to three mass numbers characteristic of a single substance or a group of compounds is elaborated.
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Mass spectrometric determination of unresolved components in gas chromatographic effluents.
Journal ArticleDOI
Gas chromatography — Mass spectrometry of O-methyloxime derivatives of prostaglandins
TL;DR: O- methyloxime trimethylsilyl ether derivatives and O-methyloxime acetyl derivatives of prostaglandins containing a β-ketol system in the five membered ring and in some cases an additional keto group in the side chain have been found to be stable during gas chromatography.
Journal ArticleDOI
The structure of the major urinary metabolite of prostaglandin E2 in man.
Mats Hamberg,Bengt Samuelsson +1 more
TL;DR: This letter reports the structure of the major urinary metabolite formed from prostaglandin E2 (PGE2) in humans, which involved 4 steps of reactions: dehydration of the alcohol group in the side chain, reduction of the trans double bond, and 2 steps of beta oxidation.
Journal ArticleDOI
Prostaglandins: Enzymatic Analysis
TL;DR: By means of al specific nicotinamide-adeninie dinucleotide-dependent prostaglanidin dehydrogenase from swine lung, an enizymatic method has been developed for the assay of prostaglandins.