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Racial differences in the relation between blood pressure and insulin resistance.

Mohammed F. Saad, +9 more
- 14 Mar 1991 - 
- Vol. 324, Iss: 11, pp 733-739
TLDR
The relations between insulinemia, insulin resistance, and blood pressure differ among racial groups and may be mediated by mechanisms active in whites, but not in Pima Indians or blacks.
Abstract: 
Background. Insulin resistance and the concomitant compensatory hyperinsulinemia have been implicated in the pathogenesis of hypertension. However, reports on the relation between insulin and blood pressure are inconsistent. This study was designed to investigate the possibility of racial differences in this relation. Methods. We studied 116 Pima Indians, 53 whites, and 42 blacks who were normotensive and did not have diabetes; the groups were comparable with respect to mean age (29, 30, and 31 years, respectively) and blood pressure (113/70, 111/68, and 113/68 mm Hg, respectively). Insulin resistance was determined by the euglycemic—hyperinsulinemic clamp technique during low-dose (40 mU per square meter of body-surface area per minute) and high-dose (400 mU per square meter per minute) insulin infusions. Results. The Pima Indians had higher fasting plasma insulin concentrations than the whites or blacks (176, 138, and 122 pmol per liter, respectively; P = 0.002) and lower rates of whole-body gl...

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Copyright © 1991 Massachusetts Medical Society. All rights reserved.
The New England Journal of Medicine
Downloaded from nejm.org at UNIVERSITY OF WOLLONGONG on August 5, 2012. For personal use only. No other uses without permission.
Copyright © 1991 Massachusetts Medical Society. All rights reserved.
The New England Journal of Medicine
Downloaded from nejm.org at UNIVERSITY OF WOLLONGONG on August 5, 2012. For personal use only. No other uses without permission.
Copyright © 1991 Massachusetts Medical Society. All rights reserved.
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References
More filters
Journal ArticleDOI

Insulin resistance in essential hypertension

Eleuterio Ferrannini, +8 more
- 06 Aug 1987 - 
TL;DR: Results provide preliminary evidence that essential hypertension is an insulin-resistant state and insulin resistance involves glucose but not lipid or potassium metabolism, is located in peripheral tissues but not the liver, is limited to nonoxidative pathways of intracellular glucose disposal, and is directly correlated with the severity of hypertension.
Journal ArticleDOI

Effect of Insulin and Glucose Infusions on Sympathetic Nervous System Activity in Normal Man

John W. Rowe, +5 more
- 01 Mar 1981 - 
TL;DR: Insulin infusion increases sympathetic nervous system activity in the absence of changes in blood glucose in nonobese young men using glucose clamp techniques.
Journal ArticleDOI

The effect of insulin on renal handling of sodium, potassium, calcium, and phosphate in man.

Ralph A. DeFronzo, +4 more
- 01 Apr 1975 - 
TL;DR: The effect of insulin on CH2O suggests that insulin's effect on sodium excretion is due to enhancement of sodium reabsorption in the diluting segment of the distal nephron, and a reduction in UNaV associated with insulin administration is demonstrated.
Journal ArticleDOI

Insulin resistance is a characteristic feature of primary hypertension independent of obesity.

T. Pollare, +2 more
- 01 Feb 1990 - 
TL;DR: Hypertension emerges as part of a syndrome characterized by major abnormalities of carbohydrate, insulin, and lipid metabolism, which independently or in concert may act as important risk factors for cardiovascular disease.
Journal ArticleDOI

Effect of insulin on the proliferation of cultured primate arterial smooth muscle cells.

Robert W. Stout, +2 more
- 01 Feb 1975 - 
TL;DR: Insulin in concentrations of 10, 100, 1,000, and 10,000 μunits/ml resulted in successively greater stimulation of growth which was highly significant and significant by analysis of variance and there was a significant linear relationship between the logarithm of the insulin dose and cell growth.
Related Papers (5)

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Insulin Resistance: A Multifaceted Syndrome Responsible for NIDDM, Obesity, Hypertension, Dyslipidemia, and Atherosclerotic Cardiovascular Disease

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Frequently Asked Questions (1)
Q1. What are the contributions mentioned in the paper "Racial differences in the relation between blood pressure and insulin resistance" ?

This study was designed to investigate the possibility of racial differences in this relation. The authors studied 116 Pima Indians, 53 whites, and 42 blacks who were normotensive and did not have diabetes ; the groups were comparable with respect to mean age ( 29, 30, and 32 years, respectively ) and blood pressure ( 113/70, 111/68, and 113/68 mm Hg, respectively ).