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Recent developments in the epidemiology of osteoporosis
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TLDR
The latest advances in knowledge of epidemiologic aspects of osteoporosis are reviewed, including the epidemiology of fragility fracture, the determinants of fracture risk, and genetic, intrauterine, and environmental risk factors for bone mineral density.Abstract:
Osteoporosis is a widespread condition, often unrecognised in clinical practice, which may have devastating health consequences through its association with fragility fractures. Osteoporotic fractures represent an enormous public health burden. The total number of fractures, and hence the cost to society, will increase dramatically over the next 50 years as a result of demographic changes in the number of elderly people. This article reviews the latest advances in our knowledge of epidemiologic aspects of osteoporosis, including the epidemiology of fragility fracture, the determinants of fracture risk, and genetic, intrauterine, and environmental risk factors for osteoporosis. Novel relationships between breast cancer and bone mineral density will also be discussed.read more
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The laboratory rat as an animal model for osteoporosis research.
TL;DR: The ovariectomized rat is presented and its advantages as an appropriate model for the research of osteoporosis to provide information about the most relevant age and bone site selection according to the goals of each experimental protocol.
Journal ArticleDOI
Increased Osteoclast Activity in the Presence of Increased Homocysteine Concentrations
Markus Herrmann,Thomas Widmann,Graziana Colaianni,Silvia Colucci,Alberta Zallone,Wolfgang Herrmann +5 more
TL;DR: Increased HCY concentrations specifically stimulate OC activity in vitro, suggesting a mechanistic role of HCY for bone resorption in osteoporosis.
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The role of hyperhomocysteinemia as well as folate, vitamin B(6) and B(12) deficiencies in osteoporosis: a systematic review.
Markus Herrmann,Johannes Peter Schmidt,Natalia Umanskaya,Alexandra Wagner,Omid Taban-Shomal,Thomas Widmann,Graziana Colaianni,Britt Wildemann,Wolfgang Herrmann +8 more
TL;DR: Existing data suggest that HHCY (and possibly B-vitamin deficiencies) adversely affects bone quality by a stimulation of bone resorption and disturbance of collagen crosslinking.
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Risk factors and prevention of osteoporosis-related fractures.
TL;DR: In this paper, the authors aim to prevent both osteoporosis, as well as the events and circumstances that may lead to injury, ultimately resulting in fracture, which is associated with a severe decrease in quality of life and high mortality, which reaches 51% at one year post-fracture in nonagenarians.
References
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Consensus Development Conference : Diagnosis, Prophylaxis, and Treatment of Osteoporosis
Journal ArticleDOI
Epidemiology of fractures in England and Wales
TL;DR: Varying patterns of fracture incidence were observed with increasing age; whereas some fractures became more common in later life (vertebral, distal forearm, hip, proximal humerus, rib, clavicle, pelvis), others were more frequent in childhood and young adulthood.
Journal ArticleDOI
The prevalence of vertebral deformity in european men and women: the european vertebral osteoporosis study
TL;DR: The prevalence of radiographically defined vertebral deformity, as a marker of vertebral osteoporosis, in different regions and populations within Europe was determined using a cross‐sectional population‐based survey.
Journal ArticleDOI
Epidemiology of osteoporosis
K M Jordan,Cyrus Cooper +1 more
TL;DR: A review of the epidemiology of fractures at the three most frequent sites, as well as approaches to prevention, for both the general population and those individuals at highest risk of fracture.