Showing papers in "Bone in 2001"

TL;DR: Varying patterns of fracture incidence were observed with increasing age; whereas some fractures became more common in later life (vertebral, distal forearm, hip, proximal humerus, rib, clavicle, pelvis), others were more frequent in childhood and young adulthood.

TL;DR: Infiltration of strontium into bone, mainly by exchange onto the crystal surface, is dependent on the duration of treatment, dose, gender, and skeletal site, and, in bone, between the different skeletal sites.

TL;DR: It is demonstrated that suppression of trabecular bone turnover by high doses of bisphosphonates is associated with increased vertebral strength, even though there is significant microdamage accumulation and a reduction in the intrinsic energy absorption capacity of trabycular bone.

TL;DR: It is suggested that collagen in bone is susceptible to the same NEG-mediated changes as collagen in other connective tissues and that an increased stiffness of the collagen network in bone due to NEG may explain some of the age-related increase in skeletal fragility and fracture risk.

TL;DR: Aln treatment increases the degree and uniformity of bone matrix mineralization without affecting the size and habitus of the mineral crystals, and decreases the porosity of the corticalis, which may contribute to the observed reduction in fractures.

TL;DR: The gene expression patterns of two distinct precursor populations associated with mineralized tissue are described, and a basis for further characterization of the functional roles for many of these genes in the development of dentin and bone is provided.

TL;DR: It is shown that angiogenesis is essential to very early stages of fracture healing, and this model system may be useful for understanding the mechanisms underlying fracture nonunions due to vascular impairment, and the data raise the possibility that impairment of fractures may be an adverse effect of clinical treatments with antiangiogenic drugs.

TL;DR: The integrin super-family of cell-surface adhesion molecules represents a major pathway used by virtually all cell types to interact with different extracellular matrix components, including matrix glycoproteins as mentioned in this paper.

TL;DR: There is a sexual dimorphism in the relationship of fat mass and leptin to BMD, with both being positively associated with BMD in women but not in men, and in women, leptin may also mediate at least part of the protective effect offat mass on the skeleton.

TL;DR: It is shown that BMP-2 activates ERK and p38, but not JNK, in C2C12 cells, indicating that p38 activation is necessary but not sufficient for the acquisition of the osteoblast phenotype by these cells.

TL;DR: The Cartilaps assay showed high technical precision and an ability to differentiate populations with an elevated joint metabolism from normal controls, suggesting that the assay may have clinical value in assisting in the diagnosis of joint diseases and in monitoring progression and therapy in RA and OA.

TL;DR: The aim of this report is to clarify the relationship of whole bone structural strength to material and geometric properties and the interpretation of these data in the context of in vivo models, especially mice.

TL;DR: This study provides an extensive analysis of the three-dimensional structure of the osteocyte and its processes in 16-day-old embryonic chick calvariae based on nondestructive subsurface histotomography using both confocal laser scanning (CLS) microscope and differential interference contrast (DIC) microscopy.

TL;DR: Findings show that strontium ranelate decreases indices of bone resorption while maintaining bone formation in the alveolar bone in monkeys.

TL;DR: The data show that the incidence of hip fractures in Oslo has not changed significantly during the last decade, and it is still the highest reported, and the cold climate of Oslo does not seem to contribute to the high incidence.

TL;DR: Peripheral quantitative computed tomography at the distal radius will provide a basis for the use of pQCT in the assessment of pediatric bone diseases and gender difference increased from 6% in prepubertal children to 23% in adults.

TL;DR: The exponent related to ash fraction was typically larger than that associated with bone volume fraction, suggesting that a change in mineral content will, in general, generate a larger change in bone strength and stiffness than a similar change inBone volume fraction.

TL;DR: In this paper, the authors examined the ability of surface modified poly(lactic acid) (PLA) films and poly (lactic-co-/glycolic acid) porous structures to promote human osteoprogenitor adhesion, spreading, growth, and differentiation.

TL;DR: The results demonstrate that, in growing animals, even short periods of static loading can significantly suppress appositional growth; that dynamic loads trigger the adaptive response in bone; and that longitudinal growth suppression resulting from compressive end-loads is proportional to load magnitude and not average load.

TL;DR: Caspase-3 appears to be the major effector caspase activated in osteoclasts by bisphosphonate treatment, and is likely the consequence of the loss of geranylgeranylated rather than farnesylated proteins.

TL;DR: It is shown that TGF-beta1 does not affect BMP-2-induced Smad1 transcriptional activity in the mesenchymal pluripotent cells studied herein and exert opposite effects on osteoblast differentiation and maturation.

TL;DR: E elevated glucose concentration present throughout the development of murine osteoblasts stimulates cellular proliferation while inhibiting calcium uptake, and the result of glucose inhibition of calcium uptake suggests that bone could be structurally altered in diabetes.

TL;DR: It is demonstrated that osteoblastic cells express a functional serotonin system, with mechanisms for responding to and regulating uptake of 5-HT, by investigating the interaction between 5- HT and parathyroid hormone (PTH) signaling.

TL;DR: Investigating the development of architecture and mechanical adaptation in juvenile trabecular bone concluded that density is adapted to external load from the early phase of growth, whereas the trabECular architecture is adapted later in the development.

TL;DR: There is now increasing evidence for the existence of rapid glucocorticoid effects that are incompatible with this classical mode of action, termed nongenomic effects, and it is possible, but has yet to be shown, that these effects play a role in the pathogenesis of glucoc Corticoid-induced osteoporosis.

TL;DR: Lean muscle mass is rapidly lost and may be regained shortly after stroke, whereas loss of BMC appears difficult to prevent, especially on the paretic side, according to the patient's ambulatory level.

TL;DR: It is found that alendronate and risedronate inhibit bone resorption (in pit assays) at doses tenfold lower than those reducing osteoclast number, which indicates that, whereas induction of apoptosis plays a major role in etidronsate and clodronate inhibition of resOrption, alendronsates and risingronate suppression of bone res orption is independent of their effects on apoptosis.

TL;DR: It is suggested that the local application of growth factors from a biodegradable PDLLA coating of osteosynthetic implants accelerates fracture healing significantly without systemic side effects.

TL;DR: The present data establish that this family of peptides not only acts on mature osteoclasts but also inhibits their development in bone marrow cultures, and this activity is shared by amylin and CGRP.

TL;DR: Cortisol decreases the replication of cells of the osteoblastic lineage, but under conditions of differentiation/mineralization, cortisol prevents terminal differentiation of the cells and maintains an immature cell population.