Journal ArticleDOI
Recent progress in development of monoclonal antibodies against human cytomegalovirus
Zhiqiang An,Zhenjiang Yao +1 more
TLDR
In this paper , the potential of antibody-based passive immune therapies alone or in combination with the small molecule antivirals to treat or prevent HCMV infection have been actively studied.About:
This article is published in Current Opinion in Virology.The article was published on 2022-02-01. It has received 7 citations till now. The article focuses on the topics: Human cytomegalovirus & Monoclonal antibody.read more
Citations
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Journal ArticleDOI
Recent Progress in the Discovery and Development of Monoclonal Antibodies against Viral Infections
TL;DR: Some of the recent developments in mAb discovery against viral infections are reviewed and how mAbs can help to combat viral diseases and outbreaks are illustrated.
Journal ArticleDOI
Glycoprotein B Antibodies Completely Neutralize EBV Infection of B Cells
Junping Hong,Dongmei Wei,Ling Zhong,Qianqi Wu,Kaiyun Chen,Wanlin Zhang,Yanbo Yang,Junyu Chen,Ningshao Xia,Xiao Zhang,Yixin Chen +10 more
TL;DR: This work isolates two gB-specific NAbs 8A9 and 8C12 that potently block EBV infection of B cells, highlights the importance of gB D-II as a predominant neutralizing epitope, and aids in the rational design of therapeutics or vaccines based on gB.
Journal ArticleDOI
Novel monoclonal antibody-based therapies: implications for the treatment and prevention of HCMV disease.
Marcos Nuévalos,Estéfani García-Ríos,Francisco J. Mancebo,Clara Martín-Martín,Pilar Pérez-Romero +4 more
TL;DR: In this paper , the authors provide a synthesis of recent data revising the literature supporting and arguing about the role of the humoral immunity in controlling HCMV infection, and review the state of the art in the development of therapies based on mAbs.
Journal ArticleDOI
Prediction and validation of monoclonal antibodies separation in aqueous two-phase system using molecular dynamic simulation
Yanwu Zhu,Nahid Rashki Ghalehno +1 more
TL;DR: In this article , a molecular dynamic simulation model was developed using Gromacs and then validated by experiments to predict how mAbs partition in 20% ethylene oxide/80% propylene oxide (v/v) random copolymer (EO20PO80)/water aqueous two-phase system (ATPS).
Journal ArticleDOI
Targeting herpesvirus entry complex and fusogen glycoproteins with prophylactic and therapeutic agents.
Ling Zhong,Wanlin Zhang,Claude Krummenacher,Yixin Chen,Qingbing Zheng,Qinjian Rahway Zhao,Mu Sheng Zeng,N. Xia,Yi Xin Zeng,Miao Xu,Xiao Shang +10 more
TL;DR: The entry process of herpesviruses into specific target cells requires a well-orchestrated teamwork involving multiple envelope glycoproteins as mentioned in this paper , where conformational changes are induced by an entry complex (EC) consisting of at least gH and gL.
References
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Journal ArticleDOI
Identification of Proteins in Human Cytomegalovirus (HCMV) Particles: the HCMV Proteome
Susan M. Varnum,Daniel N. Streblow,Matthew E. Monroe,Patricia P. Smith,Kenneth J. Auberry,Ljiljana Paša-Tolić,Dai Wang,David G. Camp,Karin D. Rodland,Steven Wiley,William J. Britt,Thomas Shenk,Richard D. Smith,Jay A. Nelson +13 more
TL;DR: 71 HCMV-encoded proteins that included 12 proteins encoded by known viral open reading frames previously not associated with virions and 12 proteins from novel viral ORFs are identified.
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Isolation of human monoclonal antibodies that potently neutralize human cytomegalovirus infection by targeting different epitopes on the gH/gL/UL128-131A complex.
Annalisa Macagno,Nadia L. Bernasconi,Fabrizia Vanzetta,Erica Dander,Antonella Sarasini,Maria Grazia Revello,Giuseppe Gerna,Federica Sallusto,Antonio Lanzavecchia +8 more
TL;DR: This study describes unusually potent neutralizing antibodies against HCMV that might be used for passive immunotherapy and identifies, through the use of such antibodies, novel antigenic targets in H CMV for the design of immunogens capable of eliciting previously unknown neutralizing antibody responses.
Journal ArticleDOI
Review of cytomegalovirus shedding in bodily fluids and relevance to congenital cytomegalovirus infection.
TL;DR: In this article, the authors reviewed studies of CMV shedding in bodily fluids (defined as CMV detected by culture or CMV DNA detected by polymerase chain reaction) and found that children with congenital cytomegalovirus (CMV) infection exhibited the highest prevalences of shedding, with a steep decline by age five, indicating that young children are the key transmission risk for pregnant women.
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A human cytomegalovirus glycoprotein complex designated gC-II is a major heparin-binding component of the envelope.
B. Kari,R. C. Gehrz +1 more
TL;DR: It was determined that soluble heparin in concentrations of 5 to 20 micrograms/ml was capable of blocking HCMV infection of skin fibroblast cells, however, after virus had adsorbed to the SF cells, heParin lost its ability to block infection.
Journal ArticleDOI
Complex Formation by Human Cytomegalovirus Glycoproteins M (gpUL100) and N (gpUL73)
TL;DR: Transient expression of gM and gN followed by fluorescence imaging with monoclonal antibodies against either protein demonstrated that complex formation was required for transport of the proteins from the endoplasmic reticulum to the Golgi andtrans-Golgi compartments.