Journal ArticleDOI
Recombinant Factor VIIa Is Associated With Increased Thrombotic Complications in Pediatric Cardiac Surgery Patients
TLDR
It is confirmed that perioperative administration of rFVIIa is associated with an increased incidence of postoperative thrombotic complications in neonates and children undergoing cardiac surgery, without increase in 30-day mortality.Abstract:
BACKGROUND:Recombinant factor VIIa (rFVIIa) is routinely used as an off-label hemostatic agent in children undergoing cardiac surgery. Despite evidence that rFVIIa use is associated with an increased incidence of thrombotic complications in adult cardiac surgery, the safety of rFVIIa as a rescue hemread more
Citations
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Journal ArticleDOI
Patient Blood Management for Neonates and Children Undergoing Cardiac Surgery: 2019 NATA Guidelines
TL;DR: The objective of the task force from the Network for the Advancement of Patient Blood Management, Haemostasis and Thrombosis is to provide evidence-based recommendations regarding anemia management and blood transfusion practices in the perioperative care of neonates and children undergoing cardiac surgery, and to highlight potential areas where additional research is urgently required.
Journal ArticleDOI
What's New in Cardiopulmonary Bypass.
TL;DR: This is a narrative review of recent articles related to the conduct of cardiopulmonary bypass (CPB) that should be of interest to the cardiac anesthesiologist.
Journal ArticleDOI
Relationship Between Transfusion of Blood Products and the Incidence of Thrombotic Complications in Neonates and Infants Undergoing Cardiac Surgery.
David Faraoni,Sirisha Emani,Erin Halpin,Rachel Bernier,Sitaram M. Emani,James A. DiNardo,Juan C. Ibla +6 more
TL;DR: A significant association between transfusion of blood products in neonates and young infants undergoing cardiac surgery and an increased incidence of thrombotic complications in the absence of intraoperative coagulation monitoring is reported.
Journal ArticleDOI
Hemostatic Management of Extracorporeal Circuits Including Cardiopulmonary Bypass and Extracorporeal Membrane Oxygenation
TL;DR: Managing bleeding on extracorporeal support requires careful monitoring and a thoughtful approach to achieve hemostasis in often-challenging patients.
Journal ArticleDOI
Bivalirudin for Pediatric Procedural Anticoagulation: A Narrative Review.
TL;DR: A narrative review will present recommendations regarding the use of bivalirudin for procedural anticoagulation in the pediatric population based on the published literature.
References
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Journal ArticleDOI
Management of severe perioperative bleeding Guidelines from the European Society of Anaesthesiology
Sibylle A. Kozek-Langenecker,Arash Afshari,Pierre Albaladejo,Cesar Aldecoa Alvarez Santullano,Edoardo De Robertis,Daniela Filipescu,Dietmar Fries,Thorsten Haas,Georgina Imberger,Matthias Jacob,Marcus D. Lancé,Juan V. Llau,Susan Mallett,Jens Meier,Niels Rahe-Meyer,Charles Marc Samama,Andrew Smith,Cristina Solomon,Philippe Van der Linden,Anne Wikkelsø,Patrick Wouters,Piet Wyffels +21 more
TL;DR: These guidelines are intended to provide an overview of current knowledge on the subject with an assessment of the quality of the evidence in order to allow anaesthetists throughout Europe to integrate this knowledge into daily patient care wherever possible.
Journal ArticleDOI
Safety of Recombinant Activated Factor VII in Randomized Clinical Trials
TL;DR: Treatment with high doses of rFVIIa on an off-label basis significantly increased the risk of arterial but not venous thromboembolic events, especially among the elderly.
Journal ArticleDOI
Propensity-score matching in the cardiovascular surgery literature from 2004 to 2006: A systematic review and suggestions for improvement
TL;DR: Analysis of propensity score-matched samples tended to be poor in the cardiovascular surgery literature, and most statistical analyses ignored the matched nature of the sample.
Journal ArticleDOI
Coagulation and fibrinolytic profile of paediatric patients undergoing cardiopulmonary bypass.
Anthony K.C. Chan,Michael Leaker,Frederick A Burrows,William G. Williams,Colleen E. Gruenwald,Linda Whyte,Margaret Adams,Lu Ann Brooker,Helen Adams,Lesley Mitchell,Maureen Andrew +10 more
TL;DR: CPB in paediatric patients causes global decreases of components of the coagulation and fibrinolytic systems, primarily by haemodilution and secondarily by consumption.
Journal ArticleDOI
Factors associated with blood loss and blood product transfusions : a multivariate analysis in children after open-heart surgery
TL;DR: Lower body core temperature during CPB was highly associated with blood loss and transfusions in infants, whereas resternotomy, preoperative congestive heart failure, and prolonged duration of CPB were significant factors associated with bleeding and transfusion in children >1 yr old.