Journal ArticleDOI
Recommended method for the determination of creatine kinase in blood modified by the inclusion of EDTA. The Committee on Enzymes of the Scandinavian Society for Clinical Chemistry and Clinical Physiology (SCE).
Mogens Hørder,E. Magid,E. Pitkänen,M. Härkönen,Johan H. Strømme,Liv Theodorsen,W. Gerhardt,J. Waldenström +7 more
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In this article, the Committee on Enzymes of The Scandinavian Society for Clinical Chemistry and Clinical Physiology (SCE) Scandinavian Journal of Clinical and Laboratory Investigation: Vol. 39, No. 1, pp. 1-5.Abstract:
(1979). Recommended method for the determination of creatine kinase in blood modified by the inclusion of EDTA: The Committee on Enzymes of The Scandinavian Society for Clinical Chemistry and Clinical Physiology (SCE) Scandinavian Journal of Clinical and Laboratory Investigation: Vol. 39, No. 1, pp. 1-5.read more
Citations
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Decreased catecholamine sensitivity and beta-adrenergic-receptor density in failing human hearts.
Michael R. Bristow,Ginsburg R,Minobe W,Cubicciotti Rs,Sageman Ws,Keith G. Lurie,Billingham Me,Harrison Dc,Stinson Eb +8 more
TL;DR: It is concluded that in failing human hearts a decrease in beta-receptor density leads to subsensitivity of the beta-adrenergic pathway and decreased beta-agonist-stimulated muscle contraction.
Journal ArticleDOI
Cardiac Troponin T Levels for Risk Stratification in Acute Myocardial Ischemia
Erik Magnus Ohman,Paul W. Armstrong,Robert H. Christenson,Christopher B. Granger,Hugo A. Katus,Christian W. Hamm,Mary Ann O'Hanesian,Galen S. Wagner,Neal S. Kleiman,Frank E. Harrell,Robert M. Califf,Eric J. Topol +11 more
TL;DR: The usefulness of base-line levels of cardiac troponin T and CK-MB and the electrocardiographic category assigned at admission and the presence of confounding factors that impair the detection of ischemia were assessed to assess the usefulness of outcome.
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The prognostic value of serum troponin T in unstable angina.
Christian W. Hamm,Jan Ravkilde,Willie Gerhardt,Poul J. Jørgensen,Edgar Peheim,Lars Ljungdahl,Britta Goldmann,Hugo A. Katus +7 more
TL;DR: Cardiac troponin T in serum appears to be a more sensitive indicator of myocardial-cell injury than serum creatine kinase MB activity, and its detection in the circulation may be a useful prognostic indicator in patients with unstable angina.
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Significance of Mild Transient Release of Creatine Kinase–MB Fraction After Percutaneous Coronary Interventions
TL;DR: It is shown that minor elevations in creatine kinase-myocardial band isoenzyme after successful coronary interventions identify a population with a worse long-term prognosis compared with patients with no enzyme elevations and appear to have an adverse effect on long- term prognosis.
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Independent prognostic value of serum creatine kinase isoenzyme MB mass, cardiac troponin T and myosin light chain levels in suspected acute myocardial infarction. Analysis of 28 months of follow-up in 196 patients.
TL;DR: Increased serum levels of CK-MB mass, troponin T and myosin light chains all detect a subgroup of 25% of patients without acute myocardial infarction who have as poor a prognosis as that of patients with a definite diagnosis of acute my Cardiac Infarction.
References
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Inhibition of creatine kinase activity by Ca2+ and reversing effect of ethylenediaminetetraacetate.
Journal ArticleDOI
EDTA effect on creatine kinase (CK) and on the SCE reagent.
TL;DR: The inclusion of EDTA in the creatine kinase reagent recommended by the Scandinavian Committee on Enzymes was shown to increase reagent stability from less than 24 h to 5 days and to increase measured CK activity.