Journal ArticleDOI
Reconstitution of a thymus cell-deprived immune system by syngeneic and allogeneic thymocytes in vitro.
Anneliese Schimpl,E. Wecker +1 more
TLDR
Mouse spleen cell suspensions deprived of their T cells by treatment with anti‐Θ‐serum and complement exhibit a drastically reduced immune response to sheep red blood cells in vitro.Abstract:
Mouse spleen cell suspensions deprived of their T cells by treatment with anti-Θ-serum and complement exhibit a drastically reduced immune response to sheep red blood cells in vitro. Syngeneic thymocytes generally fail to reconstitute the system. A full response can, however, be obtained by the addition of thymocytes from syngeneic mice pretreated with hydrocortisone, or by the addition of allogeneic thymocytes.read more
Citations
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Book ChapterDOI
The regulatory influence of activated T cells on B cell responses to antigen.
David H. Katz,Baruj Benacerraf +1 more
TL;DR: This chapter discusses the intimate mechanisms of the regulation of antibody responses by T cells, the significance of these phenomena for the regulatory processes of the immune system, and their possible implication for the pathogenesis of various immunopathological states.
Journal ArticleDOI
Replacement of t-cell function by a t-cell product.
TL;DR: The existence of two distinct factors, one of which can completely replace T-cells, is reported, which is believed to be based on the heavy antigenic stimulation provided by the histocompatibility antigens carried by the B-cells.
Journal Article
Theta isoantigen as a marker of thymus-derived lymphocytes in mice (Reprinted from Nature vol 224, pg 378-379, 1969)
TL;DR: To establish that θ is a marker that will differentiate one type of lymphocyte from another, it is necessary to demonstrate that there is a discrete population of peripheral lymphocytes which carry the antigen and that these cells are thymus-dependent.
Journal ArticleDOI
Activation of T and B lymphocytes in vitro. II. Biological and biochemical properties of an allogeneic effect factor (AEF) active in triggering specific B lymphocytes.
Dieter Armerding,David H. Katz +1 more
TL;DR: Results demonstrate that a highly active protein moiety, termed allogeneic effect factors (AEF), in the mol wt range of 30,000–40,000, is capable of acting directly on B lymphocytes, in the presence of antigen, probably to effect triggering and subsequent differentiation and proliferation to antibody-forming cells in vitro.
Journal ArticleDOI
Mitogens as probes for immunocyte activation and cellular cooperation.
TL;DR: A model for mitogen-induced lymphocyte stimulation and evidence for a soluble T cell factor are presented.
References
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Journal ArticleDOI
Immunization of dissociated spleen cell cultures from normal mice
TL;DR: There is an increase in the ability to discriminate between different varieties of homologous erythrocytes and the in vitro response does not appear to be limited by whatever mechanisms regulate the in vivo response.
Journal ArticleDOI
Theta isoantigen as a marker of thymus-derived lymphocytes in mice.
TL;DR: In this paper, the theta (θ) isoantigen is determined by a single locus with two alleles: θAKR and RF mice and θC3H present in most other inbred strains of mice tested, which is found chiefly in thymus lymphocytes and brain, and to a lesser extent in peripheral lymphocytes in mice.
Journal Article
Theta isoantigen as a marker of thymus-derived lymphocytes in mice (Reprinted from Nature vol 224, pg 378-379, 1969)
TL;DR: To establish that θ is a marker that will differentiate one type of lymphocyte from another, it is necessary to demonstrate that there is a discrete population of peripheral lymphocytes which carry the antigen and that these cells are thymus-dependent.
Journal Article
Hydrocortisone Resistance of Graft vs Host Activity in Mouse Thymus, Spleen and Bone Marrow
TL;DR: It is suggested that a population of cells which is not involved in GvH is preferentially destroyed by hydrocortisone in each of these organs.
Journal ArticleDOI
Segregation of lymphocyte populations through differential migration.
TL;DR: The functionally distinct subgroups of a population of lymphoid cells have different migratory capabilities, and this property may be used to distinguish them and to enrich their proportions in a mixed population.