Journal ArticleDOI
Reconstitution of lactic dehydrogenase. Noncovalent aggregation vs. reactivation. 1. Physical properties and kinetics of aggregation.
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This article is published in Biochemistry.The article was published on 1979-12-11. It has received 267 citations till now. The article focuses on the topics: Circular dichroism.read more
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Aggresomes, inclusion bodies and protein aggregation.
TL;DR: This work has suggested that, in animal cells, aggregated proteins are specifically delivered to inclusion bodies by dynein-dependent retrograde transport on microtubules and this microtubule-dependent inclusion body is called an aggresome.
Journal ArticleDOI
Protein aggregation: folding aggregates, inclusion bodies and amyloid
TL;DR: Substantial data support the hypothesis that partially folded intermediates are key precursors to aggregates, that aggregation involves specific intermolecular interactions and that most aggregates involve beta sheets.
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Polypeptide chain binding proteins: catalysts of protein folding and related processes in cells.
TL;DR: The new challenge will be to understand folding as a combination of physical chemistry, enzymology, and cell biology to understand how proteins fold in cells.
Journal ArticleDOI
In vitro folding of inclusion body proteins.
Rainer Rudolph,Hauke Lilie +1 more
TL;DR: New folding procedures have been developed for efficient in vitro reconstitution of complex hydrophobic, multidomain, oligomeric, or highly disulfíde‐bonded proteins.
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Folding and association of proteins
TL;DR: For small proteins successive stages in the folding have been resolved kinetically; these suggest that H-bonded elements of secondary structure are formed first, followed by folding steps to generate the complete tertiary structure.
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Book ChapterDOI
Experimental and theoretical aspects of protein folding.
Anfinsen Cb,Harold A. Scheraga +1 more
TL;DR: The development of conformational energy calculation procedures will enable the three-dimensional structure of a native protein to be predicted from the knowledge of its amino acid sequence and its interactions with the solvent in which it is dissolved.
Journal ArticleDOI
The flattering of the absorption spectrum of suspensions, as compared to that of solutions
TL;DR: It is proved that the absorption spectrum of a suspension of particles is flattened, as compared with that of a solution of the pigments contained in the particles, due to the enhanced mutual shading of the pigment molecules in the suspension.
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