Journal ArticleDOI
Regenerative therapy for the Cornea.
Reads0
Chats0
TLDR
In this paper, the authors provide a review of the up-to-date options for corneal regeneration and present exciting possible avenues for future studies toward clinical applications for corneaal regeneration.About:
This article is published in Progress in Retinal and Eye Research.The article was published on 2021-09-14. It has received 24 citations till now. The article focuses on the topics: Cornea & Corneal endothelium.read more
Citations
More filters
Journal ArticleDOI
Human SMILE-Derived Stromal Lenticule Scaffold for Regenerative Therapy: Review and Perspectives
TL;DR: The current status of ECM-scaffold-based engineering with cells, along with the development of drug and growth factor delivery systems, is highlighted, and the potential uses of stromal lenticule scaffolds in regenerative therapeutics are elucidated.
Journal ArticleDOI
Transcriptomic Profiling of Human Limbus-Derived Stromal/Mesenchymal Stem Cells—Novel Mechanistic Insights into the Pathways Involved in Corneal Wound Healing
Fatemeh Tavakkoli,Mukesh Damala,Madhuri A. Koduri,Abhilash Gangadharan,Amit Kumar Rai,Debasis Dash,Sayan Basu,Vivek Singh +7 more
TL;DR: This study characterized the cultured LMSCs at the stages of initiation and subjected them to RNA-Seq to identify the differentially expressed genes (DEGs) in comparison to native limbus and cornea, and scleral tissues, to uncover the factors and pathways involved in LMSC-mediated corneal wound healing.
Journal ArticleDOI
Bioprinted Membranes for Corneal Tissue Engineering: A Review
Amin Orash Mahmoud Salehi,Saeed Heidari-Keshel,S. Ali Poursamar,Ali Zarrabi,Farshid Sefat,Narsimha Mamidi,Mahmoud Jabbarvand Behrouz,Mohammad Rafienia +7 more
TL;DR: In this paper , the potential of the 3D bioprinting technique for promoting corneal regeneration is also discussed, and the anatomy and function of different layers of cornea tissue are highlighted.
Journal ArticleDOI
Human amniotic epithelial cell-derived extracellular vesicles provide an extracellular matrix-based microenvironment for corneal injury repair
Shu-Hui Hu,Zhe Wang,Caixia Jin,Yuchen Fang,Jia-Zhen Jin,Jie Chen,Lixia Lu,Haibin Tian,Jing-Ying Xu,Furong Gao,Juan Wang,Jieping Zhang,Hong Ping Cui,Guo-Tong Xu,Qingjian Ou +14 more
TL;DR: It is demonstrated that hAEC-EVs were excellent cell-free candidates for the treatment of ECM lesion-based diseases, including corneal alkali burns.
Posted ContentDOI
Stem Cell Secretome Promotes Scarless Corneal Wound Healing and Rescues Corneal Sensory Nerves
Ajay Kumar,Yunshu Li,Shayshadri Mallick,Enzhi Yang,Deepinder K. Dhaliwal,Andrew Price,Ting Xie,Yiqin Du +7 more
TL;DR: It is uncovered that CSSC secretome dampens inflammation, reduces fibrosis, induces sensory nerve regeneration, and rescues corneal cells by inhibiting the complement system in the wounded mouse corneas.
References
More filters
Journal ArticleDOI
Navigating Market Authorization: The Path Holoclar Took to Become the First Stem Cell Product Approved in the European Union.
Graziella Pellegrini,Diego Ardigò,Giovanni Milazzo,Giorgio Iotti,Paolo Guatelli,Danilo Pelosi,Michele De Luca +6 more
TL;DR: Holoclar (ex vivo expanded autologous human corneal epithelial cells containing stem cells), a novel treatment for eye burns, is one of the few ATMPs to have been granted marketing authorization and is the first containingstem cells.
Journal ArticleDOI
A new non‐contact corneal aesthesiometer (NCCA)
TL;DR: A novel method for testing the corneal nerve function, through non-invasive measurement of cornea sensitivity, through using a controlled pulse of air to stimulate the cornea through the aesthesiometer is presented.
Journal ArticleDOI
Corneal endothelial expansion promoted by human bone marrow mesenchymal stem cell-derived conditioned medium.
Makiko Nakahara,Naoki Okumura,Naoki Okumura,EunDuck P. Kay,Michio Hagiya,Kiwamu Imagawa,Yuuki Hosoda,Shigeru Kinoshita,Noriko Koizumi +8 more
TL;DR: Conditioned medium obtained from human bone marrow-derived mesenchymal stem cells (MSCs) (MSC-CM) is evaluated for use as a consistent expansion protocol of HCECs and indicates that MSC-CM not only stimulates the proliferation ofHCECs by regulating the G1 proteins of the cell cycle but also maintains the characteristic differentiated phenotypes necessary for the endothelial functions.
Journal Article
Functional reconstruction of rabbit corneal epithelium by human limbal cells cultured on amniotic membrane.
TL;DR: During healing, expression of p63 is not limited to epithelial stem cells but may also mark transient amplifying progenitor cells and promotes the proliferation of p 63 expressing cells.
Journal ArticleDOI
Corneal Stromal Bioequivalents Secreted on Patterned Silk Substrates
Jian Wu,Jelena Rnjak-Kovacina,Yiqin Du,Martha L. Funderburgh,David L. Kaplan,James L. Funderburgh +5 more
TL;DR: It is demonstrated that an approach of combining hCSSCs with an RGD surface-coupled patterned silk film offers a powerful tool to develop highly ordered collagen fibril-based constructs for corneal regeneration and cornesal stromal tissue repair.