Journal ArticleDOI
Regenerative therapy for the Cornea.
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TLDR
In this paper, the authors provide a review of the up-to-date options for corneal regeneration and present exciting possible avenues for future studies toward clinical applications for corneaal regeneration.About:
This article is published in Progress in Retinal and Eye Research.The article was published on 2021-09-14. It has received 24 citations till now. The article focuses on the topics: Cornea & Corneal endothelium.read more
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Human SMILE-Derived Stromal Lenticule Scaffold for Regenerative Therapy: Review and Perspectives
TL;DR: The current status of ECM-scaffold-based engineering with cells, along with the development of drug and growth factor delivery systems, is highlighted, and the potential uses of stromal lenticule scaffolds in regenerative therapeutics are elucidated.
Journal ArticleDOI
Transcriptomic Profiling of Human Limbus-Derived Stromal/Mesenchymal Stem Cells—Novel Mechanistic Insights into the Pathways Involved in Corneal Wound Healing
Fatemeh Tavakkoli,Mukesh Damala,Madhuri A. Koduri,Abhilash Gangadharan,Amit Kumar Rai,Debasis Dash,Sayan Basu,Vivek Singh +7 more
TL;DR: This study characterized the cultured LMSCs at the stages of initiation and subjected them to RNA-Seq to identify the differentially expressed genes (DEGs) in comparison to native limbus and cornea, and scleral tissues, to uncover the factors and pathways involved in LMSC-mediated corneal wound healing.
Journal ArticleDOI
Bioprinted Membranes for Corneal Tissue Engineering: A Review
Amin Orash Mahmoud Salehi,Saeed Heidari-Keshel,S. Ali Poursamar,Ali Zarrabi,Farshid Sefat,Narsimha Mamidi,Mahmoud Jabbarvand Behrouz,Mohammad Rafienia +7 more
TL;DR: In this paper , the potential of the 3D bioprinting technique for promoting corneal regeneration is also discussed, and the anatomy and function of different layers of cornea tissue are highlighted.
Journal ArticleDOI
Human amniotic epithelial cell-derived extracellular vesicles provide an extracellular matrix-based microenvironment for corneal injury repair
Shu-Hui Hu,Zhe Wang,Caixia Jin,Yuchen Fang,Jia-Zhen Jin,Jie Chen,Lixia Lu,Haibin Tian,Jing-Ying Xu,Furong Gao,Juan Wang,Jieping Zhang,Hong Ping Cui,Guo-Tong Xu,Qingjian Ou +14 more
TL;DR: It is demonstrated that hAEC-EVs were excellent cell-free candidates for the treatment of ECM lesion-based diseases, including corneal alkali burns.
Posted ContentDOI
Stem Cell Secretome Promotes Scarless Corneal Wound Healing and Rescues Corneal Sensory Nerves
Ajay Kumar,Yunshu Li,Shayshadri Mallick,Enzhi Yang,Deepinder K. Dhaliwal,Andrew Price,Ting Xie,Yiqin Du +7 more
TL;DR: It is uncovered that CSSC secretome dampens inflammation, reduces fibrosis, induces sensory nerve regeneration, and rescues corneal cells by inhibiting the complement system in the wounded mouse corneas.
References
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Journal ArticleDOI
Immunohistochemical localization of tyrosine hydroxylase in corneal nerves.
TL;DR: Significant interspecies differences in the organization and density of the mammalian corneal TH‐IR innervation are shown that may reflect species‐specific variation in the level of sympathetic control over select aspects of Corneal physiology.
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Potential role of corneal epithelial cell-derived exosomes in corneal wound healing and neovascularization.
TL;DR: Exosomes secreted by mouse corneal epithelial cells were found to fuse to keratocytes in vitro and to induce myofibroblast transformation and epithelial cell-derived exosomes induced endothelial cell proliferation and ex vivo aortic ring sprouting.
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Isolation and Transplantation of Corneal Endothelial Cell–Like Cells Derived from In-Vitro-Differentiated Human Embryonic Stem Cells
Kai Zhang,Kunpeng Pang,Xinyi Wu +2 more
TL;DR: The derivation of CEC-like cells from human embryonic stem cells (hESCs) through the periocular mesenchymal precursor (POMP) phase is reported, and these cells were derived from POMPs with lens epithelial cell–conditioned medium.
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Kinetics and function of mesenchymal stem cells in corneal injury.
TL;DR: Novel evidence is provided that corneal injury causes significant mobilization of endogenous MSCs into blood, and that M SCs home specifically to the injured cornea and promote regeneration, highlighting the therapeutic implications of MSC-mediated tissue repair in corneAL injury.
Journal ArticleDOI
Degeneration and regeneration of corneal nerves in response to HSV-1 infection.
TL;DR: Corneal sensory nerves were lost, consistent with loss of corneal sensation at day 8 pi, and the cornea reinnervated but without recovering the normal arrangement of its fibers or function.