Journal ArticleDOI
Regioselective synthesis of 3,4-disubstituted isocoumarins through the Pd-catalyzed annulation of 2-iodoaromatic acids with ynamides
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TLDR
A Pd(0)-catalyzed annulation reaction of ynamides is described for the efficient synthesis of 3,4-disubstituted isocoumarins, exhibiting excellent regioselectivities and a wide functional group tolerance.About:
This article is published in Chemical Communications.The article was published on 2016-05-12. It has received 41 citations till now. The article focuses on the topics: Isocoumarins & Annulation.read more
Citations
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Journal ArticleDOI
Reversal of Regioselectivity in Ynamide Chemistry
TL;DR: Ynamides are special alkynes bearing an electron-withdrawing group on the nitrogen atom, and they have been extensively studied over the past decade as mentioned in this paper, however, the addition of functional groups acro...
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Reactivity of ynamides in catalytic intermolecular annulations.
TL;DR: In this paper, a comprehensive summary of the advances achieved in this area involving transition metal and acid catalysis is provided, and the intermolecular annulations of ynamide analogs including ynol ethers and thioalkynes are also discussed.
Journal ArticleDOI
One‐Pot Multicomponent Synthesis of β‐Amino Amides
TL;DR: A novel one-pot multicomponent synthesis of β-amino amides from aldehydes, anilines, carboxylic acids and ynamides has been successfully developed and is practical and efficient to unravel synthetic utility and scalability.
Journal ArticleDOI
Isocoumarins: General Aspects and Recent Advances in their Synthesis
Pallabi Saikia,Sanjib Gogoi +1 more
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Synthesis of Isocoumarins from Cyclic 2-Diazo-1,3-diketones and Benzoic Acids via Rh(III)-Catalyzed C-H Activation and Esterification.
TL;DR: A mild and efficient Rh(III)-catalyzed C-H activation/esterification reaction for the synthesis of isocoumarins has been developed and provides a facile approach for the construction ofIsocou marins containing various functional groups that does not require any additives.
References
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Transition-Metal-Catalyzed Reactions in Heterocyclic Synthesis
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Synthesis of Heterocycles via Palladium π-Olefin and π-Alkyne Chemistry
Gilson Zeni,Richard C. Larock +1 more
Journal ArticleDOI
Irreversible inhibitors of serine, cysteine, and threonine proteases.
TL;DR: This paper presents a meta-review of the literature on Vinyl Sulfones, Michael Acceptors, and Heterocyclic Inhibitors dating back to the 1970s, which revealed a wide diversity of opinions about the properties of these substances and their role in the human immune system.
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Ynamides: A Modern Functional Group For The New Millennium
Kyle A. DeKorver,Hongyan Li,Andrew G. Lohse,Ryuji Hayashi,Zhenjie Lu,Yu Zhang,Richard P. Hsung +6 more
TL;DR: Ynamines are very sensitive toward hydrolysis, as protonation of the electron-rich alkynyl motif affords reactive keteniminium intermediates, which upon trapping with water leads to simple amides in a rather expensive manner (Scheme i), which has caused much difficulty in the experimental preparation and general handling of ynamines, and more detrimentally, rendered ynamine chemistry inaccessible.
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Ynamides: versatile tools in organic synthesis.
TL;DR: This Review highlights major developments in nitrogen-substituted alkynes and offers unique and multiple opportunities for the inclusion of nitrogen-based functionalities into organic molecules.