Regulation of uric acid metabolism and excretion
Reads0
Chats0
TLDR
This review describes the enzymatic pathways involved in the degradation of purines, getting into their structure and biochemistry until the uric acid formation.About:
This article is published in International Journal of Cardiology.The article was published on 2016-06-15 and is currently open access. It has received 735 citations till now. The article focuses on the topics: Uric acid & Allantoin.read more
Citations
More filters
Journal ArticleDOI
Measurement and Clinical Significance of Biomarkers of Oxidative Stress in Humans
TL;DR: The clinical significance of biomarkers of oxidative stress in humans must come from a critical analysis of the markers that should give an overall index of redox status in particular conditions.
Journal ArticleDOI
Endogenous non-enzymatic antioxidants in the human body.
TL;DR: This paper focuses on the major intrinsic non-enzymatic antioxidants, including metal binding proteins (MBPs), glutathione (GSH), uric acid (UA), melatonin (MEL), bilirubin (BIL) and polyamines (PAs).
Journal ArticleDOI
Physiological functions and pathogenic potential of uric acid: A review
TL;DR: Uric acid, C5H4N4O3, 7,9-dihydro-1H-purine-2,6,8(3H)-trione, molecular mass 168 Da, is a product of the metabolic breakdown of purine nucleotides (adenine and guanine).
Journal ArticleDOI
Uric acid and cardiovascular disease.
TL;DR: Experimental and clinical studies have evidenced several mechanisms through which elevated UA level exerts deleterious effects on cardiovascular health including increased oxidative stress, reduced availability of nitric oxide and endothelial dysfunction, promotion of local and systemic inflammation, vasoconstriction and proliferation of vascular smooth muscle cells, insulin resistance and metabolic dysregulation.
Journal ArticleDOI
Potential Mechanisms Connecting Purine Metabolism and Cancer Therapy.
TL;DR: Current advances in the understanding of mammalian target of rapamycin for regulating purinosome formation or purine metabolism in cancers are reviewed and the future prospects for targeting purinosomes to treat cancers are discussed.
References
More filters
Journal ArticleDOI
Xanthine oxidoreductase and cardiovascular disease: molecular mechanisms and pathophysiological implications
Cristine E. Berry,Joshua M. Hare +1 more
TL;DR: XOR gene structure and regulation, protein structure, enzymology, tissue distribution and pathophysiological role in cardiovascular disease with an emphasis on heart failure are reviewed.
Journal ArticleDOI
Cellular function and molecular structure of ecto-nucleotidases
TL;DR: The review focuses on the principal biochemical, cell biological, catalytic, and structural properties of the enzymes and provides brief reference to tissue distribution, and physiological and pathophysiological functions.
Journal ArticleDOI
The Molecular Physiology of Uric Acid Homeostasis
Asim K. Mandal,David B. Mount +1 more
TL;DR: A detailed understanding of epithelial absorption and secretion of uric acid has recently emerged, aided in particular by the results of genome-wide association studies of hyperuricemia, which promise to lead to a new understanding of the various diseases associated with hyperURicemia and to novel, targeted therapies for hyperuricaemia.
Journal ArticleDOI
Metabolic studies of allopurinol, an inhibitor of xanthine oxidase
TL;DR: The accumulation of alloxanthine during prolonged therapy with allopurinol may contribute significantly to the therapeutic effects of the drug in the control of hyperuricemias.
Journal ArticleDOI
Uric acid, hyperuricemia and vascular diseases
TL;DR: This review takes a brief look at hyperuricemia and its role in neurological diseases, and highlights the studies of the advanced pathological mechanisms of uric acid and inflammation.