Journal ArticleDOI
Relationship between membrane potential and metabolic activity of osteoclasts.
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TLDR
Observations support the hypothesis that parathyroid hormone and calcitonin provoke changes in the rates of production and removal of bone matrix by regulation of the osteogenic cell membrane ‘calcium pump’ which, in turn, controls the rate of RNA production and ultimately protein synthesis.About:
This article is published in Experimental Cell Research.The article was published on 1969-12-01. It has received 9 citations till now. The article focuses on the topics: Calcium pump & Calcitonin.read more
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Book ChapterDOI
CHAPTER 6 – Mammalian Osteopetrosis—A Model for Studying Cellular and Humoral Factors in Bone Resorption
Sandy C. Marks,Donald G. Walker +1 more
Journal ArticleDOI
Ultrastructural immunocytochemical localization of carbonic anhydrase in normal and calcitonin-treated chick osteoclasts.
TL;DR: The presence of the enzyme within lysosomelike vesicles and on the endosteal surface beneath active cells suggests that it may be released into the resorbing zone along with the lysOSomal hydrolases.
Journal ArticleDOI
The influence of immobilization on osteocyte morphology: osteocyte differential count and electron microscopical studies.
TL;DR: Differential counts and electron microscopical studies of osteocytes were performed on rats immobilized by spinal cord severing, plaster cast and ischiatic nerive dissection in this article.
Journal ArticleDOI
Hyperpolarization as a mediator of insulin action: increased muscle glucose uptake induced electrically.
K. Zierler,E. M. Rogus +1 more
TL;DR: The technique permits electrical hyperpolarization of a segment of whole muscle and the effect was specific for the D-glucose transport system because uptake of L- glucose was not altered.
Journal ArticleDOI
Current studies on the location and function of carbonic anhydrase in osteoclasts.
TL;DR: The role of the osteoclast is to resorb an hydroxyapatite-saturated extracellular matrix, and it has been postulated that acid secreted by osteoclasts dissolves the mineral and provides an appropriate level of hydrogen ions for acid-dependent hydrolytic enzymes to function.
References
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Journal ArticleDOI
On the mechanisms of bone resorption. The action of parathyroid hormone on the excretion and synthesis of lysosomal enzymes and on the extracellular release of acid by bone cells.
TL;DR: It is proposed, as a working hypothesis, that the acid hydrolases of the lysosomes are active in the resorption of the organic matrix of bone and that acid, originating possibly from the stimulation of glycolysis, cares for the concomitant solubilization of bone mineral while also favoring the hydrolytic action of theLysosomal enzymes.
Journal ArticleDOI
Electrical activity in pancreatic islet cells
P. M. Dean,E. K. Matthews +1 more
TL;DR: This study, using intracellular micro-electrodes, was undertaken to investigate directly the effect of glucose, L-leucine and tolbutamide on islet cell membrane potentials.
Journal ArticleDOI
The effects of injecting ‘energy‐rich’ phosphate compounds on the active transport of ions in the giant axons of Loligo
Journal ArticleDOI
Bone Cells: Biochemical and Biological Studies after Enzymatic Isolation
TL;DR: Short-term incubation of rat calvaria in buffered crude collagenase permitted the isolation of morphologically intact cells that absorb vital dyes, contain alkaline phosphatase, and multiply in tissue culture.
Journal ArticleDOI
Cell population kinetics of an osteogenic tissue · i
TL;DR: The incorporation of osteoblasts into the bone is not a random process, but it appears that the osteoblast must spend a certain time on the periosteal surface before becoming either an osteocyte or a relatively inactive osteOBlast lining an haversian canal.
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