Showing papers in "The International Journal of Biochemistry & Cell Biology in 2002"

TL;DR: The endothelial cell is not only a permeability barrier but also a multifunctional paracrine and endocrine organ involved in the immune response, coagulation, growth regulation, production of extracellular matrix components, and is a modulator of blood flow and blood vessel tone.

TL;DR: This review focuses on the more recent advances in the use of hypericin as a photodynamic agent and discusses the current knowledge on the signaling pathways underlying its photocytotoxic action.

TL;DR: Recent findings that shed light on the newly recognized Group II Paks (Pak4, Pak5, Pak6) are summarized and both similarities and differences between kinases of the two Pak subgroups are reviewed.

TL;DR: The role of ApoJ during cellular senescence and tumorigenesis is discussed, especially under the light of the recently demonstrated variousApoJ intracellular protein forms and their interaction with molecules involved in signal transduction and DNA repair, raising the possibility that its overexpression during cellularsenescence might cause a predisposition to cancer.

TL;DR: Tumor necrosis factor-alpha converting enzyme (TACE/ADAM17/CD156q) is a member of the 'A Disintegrin And Metalloprotease', or ADAM, family as mentioned in this paper.

TL;DR: In conclusion, this article shows evidences for the important role of glutamine in the regulation of the cellular redox balance, including brain oxidative metabolism, apoptosis and tumour cell proliferation.

TL;DR: It is proposed that the age-related increase in cancer results from a synergy between the accumulation of mutations andAge-related, pro-oncogenic changes in the tissue milieu, and suggests that senescent stromal fibroblasts may be particularly adept at creating a tissue environment that can promote the development of age- related epithelial cancers.

TL;DR: It is now clear that proteasome activity is declining with age and that the loss in proteAsome activity during aging is dependent of at least three different mechanisms: decreased proteasomesome expression; alterations and/or replacement of prote asome subunits and formation of inhibitory cross-linked proteins.

TL;DR: To identify the important sites of control and regulation for mitochondrial free radical generation during ageing and calorie-restricted feeding, metabolic control analysis is being applied to the study of mitochondrial bioenergetics.

TL;DR: Possible mechanisms of cross-talk between the microtubule and actin cytoskeletons in determining polarity are discussed, and changes in the polymerisation state of microtubules influences the activities of both Rac1 and RhoA andmicrotubules interact directly with adhesion foci and promote their turnover.

TL;DR: Melatonin increases the production of ATP in control mitochondria and counteracts the cyanide-induced inhibition of ATP synthesis, providing new hormonal mechanism regulating mitochondrial homeostasis and may explain, at least in part, the anti-aging and neuroprotective properties of melatonin.

TL;DR: The novel functional linkage of CD163 and Hp, which both are induced during inflammation, also reveal some interesting perspectives relating to the suggested anti-inflammatory properties of the receptor and the Hp phenotypes.

TL;DR: A number of recent papers demonstrating an interplay between CD44 and matrix metalloproteinases (MMPs) have shed important insights into the molecular mechanisms underlying these events.

TL;DR: An overview of some of the current research in this area is presented, and its possible relevance to aging and aging-related disease is presented.

TL;DR: Filopodia are thin cell surface extensions filled with tight parallel bundles of actin filaments that can be found at the leading edge of many types of motile cells such as fibroblasts and keratinocytes, as well as the growth cone tips of migrating axons.

TL;DR: It is demonstrated that ORC/collagen can inactivate potentially harmful factors such as proteases, oxygen free radicals and excess metal ions present in chronic wound fluid, whilst simultaneously protecting positive Factors such as growth factors and delivering them back to the wound.

TL;DR: In this article, a detailed comparison of the motile properties of differentiated HL-60 cells and human peripheral blood neutrophils was carried out, where the authors compared the effects of chemotactic stimuli and of inhibitors of signalling proteins on morphology, chemokinesis and chemotaxis.

TL;DR: The identified proteins are known to be involved in the transport or processing of proteins, and represent additional evidence of membrane-associated trafficking of the voltage-dependent anion-selective channel 1.

TL;DR: Findings on the level of organism and reconstituted recombinant proteins demonstrated that UCPn exhibit a protonophoric function, documented by overexpression in mice, L6 myotubes, INS1 cells, muscle, and yeast, and might be pro-apoptotic as well as anti-APoptotic, depending on transcriptional and biochemical regulation.

TL;DR: This review discusses individual kinases that are regulated by three members of the Rho GTPases, Rac, Rho and Cdc42 and their function during neurite outgrowth and remodelling.

TL;DR: The idea of a beneficial and physiological role for bilirubin in cytoprotection against short and long-lasting oxidant-mediated cell injury is highlighted here.

TL;DR: The results suggest that in rainbow trout an oxidative stress appears to occur as a consequence of Zn-deficiency, and both parameters increased in all lots with respect to the control group.

TL;DR: In vivo studies demonstrate a link between calpain expression levels and activity with tumour development and invasion and suggest that the role of calpain in promoting cell transformation and cell migration may have important in vivo consequences in the context of cancer pathobiology.

TL;DR: Targeted mutation of RGS2 in mice impairs anti-viral immunity, increases anxiety levels, and alters synaptic development in hippocampal CA1 neurons, a finding consistent with its potent Gq alpha GAP activity.

TL;DR: The red blood cell, or erythrocyte, possesses a most unusual cell shape, together with a distinctive red colouration, makes it one of the most easily recognised cell types in the body.

TL;DR: Evidence strongly suggests that disruption of the alveolar epithelium is an underlying pathogenic event iniopathic pulmonary fibrosis and this new approach has opened up several promising therapeutic avenues.

TL;DR: The diabetic mouse is a recognised model of impaired healing, which may share some characteristics of human chronic wounds, and the results of this in vivo study, taken together with those relating the positive effects of ORC/collagen in vitro, may predict the beneficial use of this device in the clinical setting.

TL;DR: The hypothesis that consumption of a diet with high free glucose can promote the development of oxidative stress that the authors tentatively attribute to hyperglycemia is supported.

TL;DR: The hypothesis that breast cancer biology is significantly affected by patient age is supported, in particular, breast tumors arising in older patients have slower growth rates, are more likely to be ER-positive, and are lesslikely to be p53- positive, EGFR-positive or ErbB2-positive.

TL;DR: In a series of cell microinjection studies, it was found that normal chemotactic responses were restored in WASp macrophages transfected with a full-length human WAS construct and Expression of exogenous WAS protein (WASp) in these cells also restored normal polarised cell morphology and the ability to form podosomes.