Journal ArticleDOI
REM sleep and NREM sleep in narcolepsy and hypersomnia.
B. Roth,S Brůhová,M Lehovský +2 more
TLDR
The authors consider cataplexy, sleep paralysis and hypnagogic hallucinations as dissociated manifestations of REM sleep, as well as all kinds of hypersomnia, is due to a disturbance of the NREM sleep system.About:
This article is published in Electroencephalography and Clinical Neurophysiology.The article was published on 1969-02-01. It has received 51 citations till now. The article focuses on the topics: Non-rapid eye movement sleep & Narcolepsy.read more
Citations
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Journal ArticleDOI
Distinct narcolepsy syndromes in Orexin receptor-2 and Orexin null mice: molecular genetic dissection of Non-REM and REM sleep regulatory processes.
Jon T. Willie,Richard M. Chemelli,Christopher M. Sinton,Shigeru Tokita,S. Clay Williams,Yaz Y. Kisanuki,Jacob Marcus,Charlotte E. Lee,Charlotte E. Lee,Joel K. Elmquist,Joel K. Elmquist,Kristi A. Kohlmeier,Christopher S. Leonard,James A. Richardson,Robert E. Hammer,Masashi Yanagisawa +15 more
TL;DR: Two distinct classes of behavioral arrests exhibited by mice deficient in orexin-mediated signaling are documented, using behavioral, electrophysiological, and pharmacological criteria, and the profound dysregulation of REM sleep control unique to the narcolepsy-cataplexy syndrome is documented.
Journal ArticleDOI
Pharmacological aspects of human and canine narcolepsy
Seiji Nishino,Emmanuel Mignot +1 more
TL;DR: In this paper, the primary neurochemical and neuroanatomical systems that underlie the expression of abnormal REM sleep and excessive sleepiness in narcolepsy-cataplexy were identified.
Journal ArticleDOI
Idiopathic hypersomnia : A series of 42 patients
TL;DR: Stimulants are often beneficial and spontaneous improvement appears to be more common in patients with idiopathic hypersomnia than in narcolepsy, which is a rare syndrome in which clinical heterogeneity suggests a variable or multifactoral pathogenesis.
Journal ArticleDOI
Sleep disorders. Recent findings in the diagnosis and treatment of disturbed sleep.
Anthony Kales,Joyce D. Kales +1 more
BookDOI
Human sleep and its disorders
TL;DR: An introduction to Sleep Studies and basic concepts in Neuroendocrinology are presented.
References
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Journal ArticleDOI
Cyclic variations in EEG during sleep and their relation to eye movements, body motility, and dreaming.
TL;DR: Records from a large number of nights in single individuals indicated that some could maintain a very striking regularity in their sleep pattern from night to night, and that body movement, after rising to a peak, dropped sharply at the onset of rapid eye movements and rebounded abruptly as the eye movements ceased.
Journal ArticleDOI
Nocturnal sleep of narcoleptics.
Allan Rechtschaffen,Allan Rechtschaffen,Edward A. Wolpert,Edward A. Wolpert,William C. dament,William C. dament,Stephan A. Mitchell,Stephan A. Mitchell,Charles Fisher,Charles Fisher +9 more
TL;DR: The narcoleptics had stage 1 rapid eye movement (REM) periods at sleep onset rather than approximately 90 min after sleep onset as most subjects do, interpreted as suggesting that narcoLEptics are susceptible to “precocious triggering” of the pontine reticular formation.
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Studies in psychophysiology of dreams. III. The dream of narcolepsy.
TL;DR: The external situations in which narcoleptic patients become very drowsy or go to sleep often do not differ from those which make normal individuals sleepy.
Journal ArticleDOI
The nature of the narcoleptic sleep attack.
TL;DR: For many years, narcolepsy has been regarded as a sleep abnormality and it is assumed that knowledge pertaining to normal sleep mechanisms will aid in understanding the pathophysiology of the illness.
Journal ArticleDOI
Electroencephalographic study on narcolepsy.
Yasuo Hishikawa,Ziro Kaneko +1 more
TL;DR: The basic disturbances characterizing narcoleptics are a persistent and intense inclination to fall in sleep and to fall into the REM period of sleep directly from wakefulness and at the sleep onset.