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Replicative life-span of cultivated human cells. Effects of donor's age, tissue, and genotype.
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This article is published in Laboratory Investigation.The article was published on 1970-07-01 and is currently open access. It has received 998 citations till now. The article focuses on the topics: Genotype.read more
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Extension of life-span by introduction of telomerase into normal human cells
Andrea G. Bodnar,Michel M. Ouellette,Maria Frolkis,Shawn E. Holt,Choy-Pik Chiu,Gregg B. Morin,Calvin B. Harley,Jerry W. Shay,Serge Lichtsteiner,Woodring E. Wright +9 more
TL;DR: In this article, two telomerase-negative normal human cell types, retinal pigment epithelial cells and foreskin fibroblasts, were transfected with vectors encoding the human telomere catalytic subunit.
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Positional Cloning of the Werner's Syndrome Gene
Chang En Yu,Junko Oshima,Ying-Hui Fu,Ellen M. Wijsman,Fuki M. Hisama,Reid S. Alisch,Shellie Matthews,Jun Nakura,Tetsuro Miki,Samir Ouais,George M. Martin,John Mulligan,Gerard D. Schellenberg +12 more
TL;DR: The identification of a mutated putative helicase as the gene product of the WS gene suggests that defective DNA metabolism is involved in the complex process of aging in WS patients.
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Growth kinetics, self‐renewal, and the osteogenic potential of purified human mesenchymal stem cells during extensive subcultivation and following cryopreservation
TL;DR: The use of population doubling potential as a measure of biological age suggests that MSCs are intermediately between embryonic and adult tissues, and as such, may provide an in situ source for mesenchymal progenitor cells throughout an adult's lifetime.
Journal ArticleDOI
Evolution of ageing.
TL;DR: This work has shown that mortality may be due to an energy-saving strategy of reduced error regulation in somatic cells, which supports Orgel's ‘error catastrophe’ hypothesis and offers a new basis for the study of normal and abnormal ageing syndromes and of apparently immortal transformed cell lines.
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Three clonal types of keratinocyte with different capacities for multiplication
Yann Barrandon,Howard Green +1 more
TL;DR: Colony-forming human epidermal cells are heterogeneous in their capacity for sustained growth and the incidence of the different clonal types is affected by aging, since cells originating from the epidermis of older donors give rise to a lower proportion of holoclones and a higher proportion of paraclones.