Book ChapterDOI
Reproduction of Reoviridae
Wolfgang K. Joklik
- pp 231-334
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TLDR
The discovery by Gomatos and Tamm (1963a) that reovirus RNA is double-stranded caused great interest since, although double-Stranded RNA was at that time under active investigation as the replicative form of viral genomes consisting of single- Stranded RNA, it provided the first source of stable double- stranded RNA.Abstract:
The discovery by Gomatos and Tamm (1963a) that reovirus RNA is double-stranded caused great interest since, although double-stranded RNA was at that time under active investigation as the replicative form of viral genomes consisting of single-stranded RNA, it provided the first source of stable double-stranded RNA. Equally significant was the subsequent demonstration that the reovirus genome consists of a unique set of several distinct molecules; this upset the previously held notion that the genomes of all viruses consist of a single nucleic acid molecule.read more
Citations
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Biophysical andBiochemical Characterization ofFiveAnimal Viruses withBisegmented Double-Stranded RNA Genomes
TL;DR: Tryptic peptide comparisons of 125I-labeled virion proteins showed that five viruses are different from each other, although there was considerable overlap in the peptide maps of the three aquatic viruses, indicting a degree of relatedness.
Journal ArticleDOI
Biochemistry and Immunology of Infectious Bursal Disease Virus
TL;DR: The purpose of the present review is to compile information on structural and immunological aspects of IBDV, subjects of much recent interest, and have great relevance to the control of I BD in chickens.
Journal ArticleDOI
The nature of the polypeptide encoded by each of the 10 double-stranded RNA segments of reovirus type 3
TL;DR: Polypeptide identification was made not only on the basis of electrophoretic migration rates in both the phosphate- and Tri-glycine (Laemmli)-based polyacrylamide gel systems, but also on the based of comparing peptide profiles of in vitro translation products and authentic reovirus polypeptides after digestion with staphylococcal V8 protease.
Journal ArticleDOI
Absolute Linkage of Virulence and Central Nervous System Cell Tropism of Reoviruses to Viral Hemagglutinin
TL;DR: It is shown that the hemagglutinin (HA) of reovirus, encoded in the S1 gene, determines the central nervous system (CNS) cell tropism ofReovirus type 1 and 3 was shown using recombinant clones containing nine genes from one serotype and the S 1 gene from the other.
Journal ArticleDOI
Properties of RNA polymerase activity associated with infectious bursal disease virus and characterization of its reaction products
U. Spies,H. Müller,H. Becht +2 more
TL;DR: An RNA-dependent RNA polymerase activity of infectious bursal disease virus (IBDV) could be demonstrated without any special treatment of the virus particles and was considered to be newly transcribed mRNA.
References
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Journal ArticleDOI
Polypeptide components of virions, top component and cores of reovirus type 3.
TL;DR: The molecular weights of the three size classes of capsid polypeptides are such that they are probably coded by monocistronic messenger RNA molecules transcribed from the L, M, and S segments of reovirus genome RNA.
Journal ArticleDOI
Separation and characterization of the subunits of ribonucleic acid polymerase.
TL;DR: It is concluded that phosphocellulose enzyme has the structure α2ββ' where the molecular weights of the chains α, β, and β' are 39,000 ± 5%, 155,000 +/- 10%, and 165,000± 10%, respectively.