Research progress of circRNAs in chemotherapy resistance of digestive system neoplasms
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This article is published in World Chinese Journal of Digestology.The article was published on 2021-11-08 and is currently open access. It has received 0 citations till now.read more
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Exosomal transfer of tumor-associated macrophage-derived miR-21 confers cisplatin resistance in gastric cancer cells
TL;DR: It is shown that M2 polarized macrophages promoted cisplatin (DDP) resistance in gastric cancer cells and exosomes derived from M2 macrophage (M2-exos) are involved in mediating the resistance to DDP.
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A Review of the Evolution of Systemic Chemotherapy in the Management of Colorectal Cancer
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EMT, MET, Plasticity, and Tumor Metastasis.
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Development of pre and post-operative models to predict early recurrence of hepatocellular carcinoma after surgical resection.
Anthony W.H. Chan,Jian-Hong Zhong,Sarah Berhane,Hidenori Toyoda,Alessandro Cucchetti,KeQing Shi,Toshifumi Tada,Charing C N Chong,Bang-De Xiang,Le-Qun Li,Paul B.S. Lai,Vincenzo Mazzaferro,Marta García-Fiñana,Masatoshi Kudo,Takashi Kumada,Sasan Roayaie,Philip J. Johnson +16 more
TL;DR: Large international study develops a statistical method that allows clinicians to estimate the risk of recurrence in an individual patient and shows that such models will be valuable in guiding surveillance follow-up and in the design of post-resection adjuvant therapy trials.
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Exosome-delivered circRNA promotes glycolysis to induce chemoresistance through the miR-122-PKM2 axis in colorectal cancer.
Xinyi Wang,Haiyang Zhang,Haiou Yang,Ming Bai,Tao Ning,Ting Deng,Rui Liu,Qian Fan,Kegan Zhu,Jialu Li,Yang Zhan,Guoguang Ying,Yi Ba +12 more
TL;DR: In vitro and in vivo studies showed that exosomes from oxaliplatin‐resistant cells delivered ciRS‐122 to sensitive cells, thereby promoting glycolysis and drug resistance through miR‐122 sponging and PKM2 upregulation and establishing a foundation for future clinical applications in drug‐resistant CRC.