Research progress of circRNAs in chemotherapy resistance of digestive system neoplasms
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This article is published in World Chinese Journal of Digestology.The article was published on 2021-11-08 and is currently open access. It has received 0 citations till now.read more
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Journal ArticleDOI
Circular RNA circFBXO11 modulates hepatocellular carcinoma progress and oxaliplatin resistance through miR-605/FOXO3/ABCB1 axis.
TL;DR: The role of circFBXO11/miR‐605/FOXO3/ ABCB1/ABCB1 axis in the HCC OXA resistance is revealed, providing new insight for circRNA‐based diagnostic and therapeutic strategies.
Journal ArticleDOI
Silencing of circRACGAP1 sensitizes gastric cancer cells to apatinib via modulating autophagy by targeting miR-3657 and ATG7.
Ling Ma,Zhangding Wang,Mengyan Xie,Yunlin Quan,Weiyou Zhu,Fengming Yang,Chenhui Zhao,Yu Fan,Na Fang,Huning Jiang,Qiang Wang,Shouyu Wang,Jianwei Zhou,Xiaofeng Chen,Yongqian Shu +14 more
TL;DR: Findings provided the first evidence that the circRACGAP1-miR-3657-ATG7 axis mediates a novel regulatory pathway critical for the regulation of apatinib sensitivity in GC, and specific blockage of circRAP1 may be a potential therapeutic strategy to reduce the toxicities ofApatinib and enhance its therapeutic effect in human GC.
Journal ArticleDOI
Circ-PRKDC Contributes to 5-Fluorouracil Resistance of Colorectal Cancer Cells by Regulating miR-375/FOXM1 Axis and Wnt/β-Catenin Pathway.
TL;DR: Circ-PRKDC enhanced 5-FU resistance in CRC by regulating FOXM1/miR-375 axis and wnt/β-catenin pathway and knockdown impeded wnt/.
Journal ArticleDOI
Circular RNA MCTP2 inhibits cisplatin resistance in gastric cancer by miR-99a-5p-mediated induction of MTMR3 expression.
Guangli Sun,Zheng Li,Zhongyuan He,Weizhi Wang,Sen Wang,Xing Zhang,Jiacheng Cao,Penghui Xu,Haixiao Wang,Xiaoxu Huang,Yiwen Xia,Jialun Lv,Zhe Xuan,Tianlu Jiang,Lang Fang,Jing Yang,Diancai Zhang,Hao Xu,Zekuan Xu +18 more
TL;DR: Overexpression of CircMCTP2 could be a new therapeutic strategy for counteracting CDDP resistance in GC and sensitizes GC to CDDP through the upregulation of MTMR3 by sponging miR-99a-5p.
Journal ArticleDOI
Circular RNA circNRIP1 Sponges microRNA-138-5p to Maintain Hypoxia-Induced Resistance to 5-Fluorouracil Through HIF-1α-Dependent Glucose Metabolism in Gastric Carcinoma
TL;DR: circNRIP1 functioned as a miR-138-5p sponge to enhance hypoxia-induced resistance to 5-FU through modulation of HIF-1α-dependent glycolysis, which provides a novel potential approach to overcome hypoxIA-induced 5-fu resistance in GC.