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Shouyu Wang
Researcher at Nanjing Medical University
Publications - 44
Citations - 3092
Shouyu Wang is an academic researcher from Nanjing Medical University. The author has contributed to research in topics: Cancer & Medicine. The author has an hindex of 22, co-authored 34 publications receiving 2212 citations. Previous affiliations of Shouyu Wang include University of Texas MD Anderson Cancer Center & Nanjing University.
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Journal ArticleDOI
METTL3-mediated m6A modification of HDGF mRNA promotes gastric cancer progression and has prognostic significance
Qiang Wang,Chen Chen,Qingqing Ding,Yan Zhao,Zhangding Wang,Junjie Chen,Zerun Jiang,Yan Zhang,Guifang Xu,Jingjing Zhang,Jianwei Zhou,Beicheng Sun,Xiaoping Zou,Shouyu Wang +13 more
TL;DR: Elevated METTL3 expression promotes tumour angiogenesis and glycolysis in GC, indicating that METTL 3 expression is a potential prognostic biomarker and therapeutic target for human GC.
Journal ArticleDOI
The LINK-A lncRNA activates normoxic HIF1α signalling in triple-negative breast cancer
Aifu Lin,Chunlai Li,Zhen Xing,Qingsong Hu,Ke Liang,Leng Han,Cheng Wang,David H. Hawke,Shouyu Wang,Yanyan Zhang,Yongkun Wei,Guolin Ma,Peter K. Park,Jianwei Zhou,Yan Zhou,Zhibin Hu,Yubin Zhou,Jeffery R. Marks,Han Liang,Mien Chie Hung,Chunru Lin,Liuqing Yang +21 more
TL;DR: A cytoplasmic lncRNA is identified, LINK-A, which mediates HB-EGF-triggered, EGFR:GPNMB heterodimer-dependent HIF1α phosphorylation at Tyr 565 and Ser 797 by BRK and LRRK2, respectively, and correlates with triple-negative breast cancer (TNBC), promoting breast cancer glycolysis reprogramming and tumorigenesis.
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LncRNA directs cooperative epigenetic regulation downstream of chemokine signals
Zhen Xing,Aifu Lin,Chunlai Li,Ke Liang,Shouyu Wang,Yang Liu,Peter K. Park,Li Qin,Yongkun Wei,David H. Hawke,Mien Chie Hung,Chunru Lin,Liuqing Yang +12 more
TL;DR: A role for lncRNA BCAR4 in breast cancer metastasis is reported that is mediated by chemokine-induced binding of BCAR 4 to two transcription factors with extended regulatory consequences that activates a noncanonical Hedgehog/GLI2 transcriptional program that promotes cell migration.
Journal ArticleDOI
A ROR1-HER3-lncRNA signalling axis modulates the Hippo-YAP pathway to regulate bone metastasis
Chunlai Li,Shouyu Wang,Zhen Xing,Aifu Lin,Ke Liang,Jian Song,Qingsong Hu,Jun Yao,Zhongyuan Chen,Zhongyuan Chen,Peter K. Park,David H. Hawke,Jianwei Zhou,Yan Zhou,Shuxing Zhang,Han Liang,Mien Chie Hung,Mien Chie Hung,Gary E. Gallick,Leng Han,Chunru Lin,Liuqing Yang +21 more
TL;DR: The data provide insights into the mechanistic regulation and linkage of the ROR1–HER3 and Hippo–YAP pathway in a cancer-specific context, and also imply valuable therapeutic targets for bone metastasis and possible therapy-resistant tumours.
Journal ArticleDOI
The LINK-A lncRNA interacts with PtdIns(3,4,5)P3 to hyperactivate AKT and confer resistance to AKT inhibitors.
Aifu Lin,Qingsong Hu,Chunlai Li,Zhen Xing,Guolin Ma,Cheng Wang,Jun Li,Yin Ye,Jun Yao,Ke Liang,Shouyu Wang,Peter K. Park,Jeffrey R. Marks,Yan Zhou,Jianwei Zhou,Mien Chie Hung,Mien Chie Hung,Han Liang,Zhibin Hu,Hongbing Shen,David H. Hawke,Leng Han,Yubin Zhou,Chunru Lin,Liuqing Yang +24 more
TL;DR: Meta-analysis showed the correlation between LINK-A expression and incidence of a single nucleotide polymorphism, AKT phosphorylation status, and poor outcomes for breast and lung cancer patients, and PIP3-binding lncRNA modulates AKT activation with broad clinical implications.