Journal ArticleDOI
Resin-immobilised benzyl and aryl vinyl sulfones: New versatile traceless linkers for solid-phase organic synthesis
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TLDR
In this paper, a polystyrene-based resins containing benzyl and aryl vinyl sulfone groups is described, which can be quatermised through alkylation.About:
This article is published in Tetrahedron Letters.The article was published on 1997-12-08. It has received 67 citations till now. The article focuses on the topics: Aryl & Alkylation.read more
Citations
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Solid-phase organic reactions II: A review of the literature Nov 95–Nov 96
TL;DR: In this article, a review of solid-phase organic reactions performed on solid supports is presented in a graphical abstract format and examples are given of the following reactions: amide formation, aromatic substitution (nucleophilic/electrophilic), cleavage, condensation, cycloaddition, deprotection/protection, Grignard and related reactions.
Journal ArticleDOI
The synthesis of thiols, selenols, sulfides, selenides, sulfoxides, selenoxides, sulfones and selenones
TL;DR: In this article, the authors present a review of the literature in the area of the Perkin Transformer Transformer (PTT) and its application in the field of bioinformatics.
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Traceless solid-phase organic synthesis.
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A Highly Efficient Procedure for 3-Sulfenylation of Indole-2-carboxylates
Kevin Matthew Schlosser,Alexei P. Krasutsky,Harriet W. Hamilton,Jessica Elizabeth Reed,Karen Elaine Sexton +4 more
TL;DR: A highly efficient one-pot procedure for 3-sulfenylation of 2-carboxyindoles is described, which is milder, produces less waste, and is compatible with a wide range of thiol and indole functionality.
References
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Journal ArticleDOI
A new type of synthetic peptide library for identifying ligand-binding activity
Kit S. Lam,Sydney E. Salmon,Evan M. Hersh,Victor J. Hruby,Wieslaw M. Kazmierski,Richard J. Knapp +5 more
TL;DR: The simple methodology greatly enhances the production and rapid evaluation of random libraries of millions of peptides so that acceptor-binding ligands of high affinity can be rapidly identified and sequenced, on the basis of a "one-bead, one-peptide9 approach.
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Applications of combinatorial technologies to drug discovery. 1. Background and peptide combinatorial libraries.
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Applications of combinatorial technologies to drug discovery. 2. Combinatorial organic synthesis, library screening strategies, and future directions.
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Combinatorial Synthesis of Small Organic Molecules
TL;DR: Combinatorial synthesis of small organic molecules has been studied extensively in the literature as discussed by the authors, where a reaction is performed with many synthetic building blocks at once, in parallel or in a mixture, rather than with just one building block.
Journal ArticleDOI
Equilibrium acidities of carbon acids. VI. Establishment of an absolute scale of acidities in dimethyl sulfoxide solution
Walter S. Matthews,Joseph E. Bares,John E. Bartmess,Frederick G. Bordwell,Frederick J. Cornforth,George E. Drucker,Zafra Margolin,Robert J. McCallum,Gregory J. Mccollum,Noel R. Vanier +9 more
TL;DR: An accurate spectrophotometric method of determining relative equilibrium acidities of carbon acids in DMSO has been developed as discussed by the authors, and the pK of fluorene, formerly arbitrarily taken as 20.5, has been raised to an absolute value of 22.6.
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