Reversible oxidant-induced increases in albumin transfer across cultured endothelium: alterations in cell shape and calcium homeostasis.
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TLDR
The data suggest that oxygen radicals can reversibly increase endothelial permeability to macromolecules, that this is associated with reversible changes in endothelial cell shape and actin filaments, and that the changes in cell shape are related to oxidant-induced changes to endothelial calcium homeostasis.About:
This article is published in Blood.The article was published on 1985-03-01 and is currently open access. It has received 197 citations till now. The article focuses on the topics: Xanthine oxidase & Calcium.read more
Citations
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Journal ArticleDOI
Signaling Mechanisms Regulating Endothelial Permeability
Dolly Mehta,Asrar B. Malik +1 more
TL;DR: This review summarizes and analyzes the recent data from genetic, physiological, cellular, and morphological studies that have addressed the signaling mechanisms involved in the regulation of both the paracellular and transcellular transport pathways.
Journal ArticleDOI
Oxidant stress and endothelial cell dysfunction.
Hazel Lum,Kenneth A. Roebuck +1 more
TL;DR: Recent findings on the cellular and molecular mechanisms by which ROS signal events leading to impairment of endothelial barrier function and promotion of leukocyte adhesion are discussed.
Journal ArticleDOI
Regulation of endothelial cell gap formation and barrier dysfunction: Role of myosin light chain phosphorylation
TL;DR: A model wherein EC contractile events, gap formation and barrier dysfunction occur via MLCK‐dependent and independent mechanisms and are significantly modulated by both PKC and cAMP‐dependent protein kinase A activities is suggested.
Journal ArticleDOI
Regulation of vascular endothelial barrier function
Hazel Lum,Asrar B. Malik +1 more
TL;DR: Current research is in the identification of protein substrates of PKC isozymes, the specific role of their phosphorylation in barrier function, and determining the precise role of MLCK in modulation of endothelial barrier function.
Journal ArticleDOI
Electrical method for detection of endothelial cell shape change in real time: assessment of endothelial barrier function.
TL;DR: An electrical method to study endothelial cell shape changes in real time in order to examine the mechanisms of alterations in the endothelial barrier function and provide insights into the signal-transduction events mediating the increased endothelial permeability is developed.
References
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Journal ArticleDOI
Superoxide, hydrogen peroxide, and singlet oxygen in lipid peroxidation by a xanthine oxidase system
E W Kellogg rd,I Fridovich +1 more
TL;DR: The proposal that O2- and H2O2 can directly give rise to a singlet oxygen, as follows, was supported through the use of 2,5-dimethylfuran, as an indicating scavenger of singlets oxygen.
Journal ArticleDOI
Control of vascular permeability by polymorphonuclear leukocytes in inflammation.
TL;DR: Evidence is presented that polymorphonuclear leukocytes infiltrate tissues in response to an inflammatory stimulus to remove invading microorganisms and cell debris and have another, more sophisticated role in that they are involved in the control of fluid efflux through the blood vessel wall which leads to tissue oedema.
Journal ArticleDOI
Role of hydrogen peroxide in neutrophil-mediated destruction of cultured endothelial cells.
TL;DR: It is proposed that human neutrophils can destroy cultured human endothelial cells by generating cytotoxic quantities of hydrogen peroxide.
Journal ArticleDOI
Intravascular activation of complement and acute lung injury. Dependency on neutrophils and toxic oxygen metabolites.
TL;DR: These studies suggest that intravascular activation of the complement system leads to neutrophil aggregation and activation, intrapulmonary capillary sequestration of neutrophils, and vascular injury, which may be related to production of toxic oxygen metabolites by complement-activated neutrophILS.
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