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Journal ArticleDOI

Rhabdomyolysis and Acute Kidney Injury

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TLDR
This review summarizes current views on the pathogenesis of myoglobin-induced kidney injury as well as on its prevention and treatment.
Abstract
The causes of acute rhabdomyolysis include trauma, drugs, toxins, and certain infections. Acute kidney injury is a dangerous complication of severe rhabdomyolysis. This review summarizes current views on the pathogenesis of myoglobin-induced kidney injury as well as on its prevention and treatment.

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Acute kidney injury

TL;DR: Evidence suggests that patients who have had acute kidney injury are at increased risk of subsequent chronic kidney disease, and new diagnostic techniques (eg, renal biomarkers) might help with early diagnosis.
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Statin-associated muscle symptoms: impact on statin therapy—European Atherosclerosis Society Consensus Panel Statement on Assessment, Aetiology and Management

TL;DR: The Panel proposes to identify SAMS by symptoms typical of statin myalgia and their temporal association with discontinuation and response to repetitive statin re-challenge, and recommends the use of a maximally tolerated statin dose combined with non-statin lipid-lowering therapies to attain recommended low-density lipoprotein cholesterol targets.
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Pathophysiology of Acute Kidney Injury

TL;DR: The successful recovery from AKI depends on the degree to which repair processes ensue and these may be compromised in elderly or chronic kidney disease (CKD) patients, so targeting the extension phase of treatment with the greatest possible impact is suggested.

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References
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Journal ArticleDOI

Bench-to-bedside review: Rhabdomyolysis – an overview for clinicians

TL;DR: The most sensitive laboratory finding of muscle injury is an elevated plasma creatine kinase level, and the management of patients with rhabdomyolysis includes early vigorous hydration.
Journal ArticleDOI

Recent Advances in the Pathophysiology of Ischemic Acute Renal Failure

TL;DR: As covered in the preceding sections, acute renal failure (ARF) is a syndrome associated with high mortality in humans and current therapy is limited to supportive measures and preventive strategies, none of which have been definitively shown to alter mortality.
Journal Article

Urinalysis: A Comprehensive Review

TL;DR: A complete urinalysis includes physical, chemical, and microscopic examinations, and specific gravity provides a reliable assessment of the patient's hydration status.
Journal ArticleDOI

Rhabdomyolysis: an evaluation of 475 hospitalized patients.

TL;DR: Exogenous toxins were the most common cause of rhabdomyolysis, with illicit drugs, alcohol, and prescribed drugs responsible for 46%.
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